Refereed review article in scientific journal (A2)

Multimodality imaging approach to left ventricular dysfunction in diabetes: an expert consensus document from the European Association of Cardiovascular Imaging




List of AuthorsMarwick Thomas H, Gimelli Alessia, Plein Sven, Bax Jeroen J, Charron Phillippe, Delgado Victoria, Donal Erwan, Lancellotti Patrizio, Levelt Eylem, Maurovich-Horvat Pal, Neubauer Stefan, Pontone Gianluca, Saraste Antti, Cosyns Bernard, Edvardsen Thor, Popescu Bogdan A, Galderisi Maurizio, Derumeaux Genevieve

PublisherOXFORD UNIV PRESS

Publication year2022

JournalEHJ Cardiovascular Imaging / European Heart Journal - Cardiovascular Imaging

Journal name in sourceEUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING

Journal acronymEUR HEART J-CARD IMG

Volume number23

Issue number2

Start pageE62

End pageE84

Number of pages23

ISSN2047-2404

DOIhttp://dx.doi.org/10.1093/ehjci/jeab220

URLhttps://academic.oup.com/ehjcimaging/article/23/2/e62/6421639


Abstract
Heart failure (HF) is among the most important and frequent complications of diabetes mellitus (DM). The detection of subclinical dysfunction is a marker of HF risk and presents a potential target for reducing incident HF in DM. Left ventricular (LV) dysfunction secondary to DM is heterogeneous, with phenotypes including predominantly systolic, predominantly diastolic, and mixed dysfunction. Indeed, the pathogenesis of HF in this setting is heterogeneous. Effective management of this problem will require detailed phenotyping of the contributions of fibrosis, microcirculatory disturbance, abnormal metabolism, and sympathetic innervation, among other mechanisms. For this reason, an imaging strategy for the detection of HF risk needs to not only detect subclinical LV dysfunction (LVD) but also characterize its pathogenesis. At present, it is possible to identify individuals with DM at increased risk HF, and there is evidence that cardioprotection may be of benefit. However, there is insufficient justification for HF screening, because we need stronger evidence of the links between the detection of LVD, treatment, and improved outcome. This review discusses the options for screening for LVD, the potential means of identifying the underlying mechanisms, and the pathways to treatment.


Last updated on 2023-11-05 at 13:03