Refereed journal article or data article (A1)

Gastrointestinal Symptoms and Dopamine Transporter Asymmetry in Early Parkinson's Disease




List of Authors: Murtomäki Kirsi, Mertsalmi Tuomas, Jaakkola Elina, Mäkinen Elina, Levo Reeta, Nojonen Tanja, Eklund Mikael, Nuuttila Simo, LIndholm Kari, Pekkonen Eero, Joutsa Juho, Noponen Tommi,Ihalainen Toni, Kaasinen Valtteri, Scheperjans Philip

Publisher: WILEY

Publication year: 2022

Journal: Movement Disorders

Journal name in source: MOVEMENT DISORDERS

Journal acronym: MOVEMENT DISORD

Number of pages: 7

ISSN: 0885-3185

DOI: http://dx.doi.org/10.1002/mds.28986

URL: https://doi.org/10.1002/mds.28986

Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/174953225


Abstract

Background: The neurophysiological correlates of gastrointestinal symptoms (GISs) in Parkinson's disease (PD) are not well understood. It has been proposed that in patients with a gastrointestinal origin of PD dopaminergic neurodegeneration would be more symmetric.

Objectives: The aim is to assess the associations between GISs and asymmetry of nigrostriatal dopaminergic neurodegeneration in PD.

Methods: Ninety PD patients were assessed using motor and GIS scales and 123 I-FP-CIT SPECT. We calculated the asymmetry index and the predominant side of motor symptoms and dopamine transporter (DAT) imaging defect and assessed their association with GISs.

Results: There were no significant differences in GISs between symmetric and asymmetric dopaminergic defect. Left predominant defect was related to more GIS and higher constipation scores.

Conclusions: GISs were associated with left predominant reduction in putaminal DAT binding but not asymmetry per se. It remains open whether left-sided DAT deficit is related to more pronounced GI involvement or symptom perception in PD. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson Movement Disorder Society.


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Last updated on 2022-20-05 at 11:26