A1 Refereed original research article in a scientific journal
Different pattern of reduction of striatal dopamine reuptake sites in Alzheimer's disease and ageing
Authors: Kemppainen N, Marjamäki P, Röyttä M, Rinne JO
Publication year: 2001
Journal: Journal of Neural Transmission
Journal name in source: Journal of neural transmission (Vienna, Austria : 1996)
Journal acronym: J Neural Transm (Vienna)
Volume: 108
Issue: 7
First page : 827
Last page: 36
ISSN: 0300-9564
DOI: https://doi.org/10.1007/s007020170032
Abstract
Striatal dopamine reuptake sites were studied in brain samples from 14 Alzheimer's disease (AD) patients. A cocaine analogue, [3H]CFT (WIN 35,428, 2beta-carbomethoxy-3beta-(4-fluorophenyl)-tropane) was used as a radioligand to determine the number of [3H]CFT binding sites (Bmax) and their dissociation constant (Kd). In patients with AD the reduction in [3H]CFT binding in the putamen was about 50% compared to age-matched controls. In the caudate nucleus the reduction was about 33%. Thus, the putamen was more severely affected. No change was observed in Kd values between AD patients and controls. Brain samples from 37 healthy controls (aged from 8 to 91 years) were used to study the changes in striatal [3H]CFT binding with increasing age. The Bmax of [3H]CFT uptake was reduced both in the putamen and in the caudate nucleus. The average decline per decade was greater in the caudate nucleus (7.3%) than in the putamen (5.5%). In conclusion, the pattern of changes in AD is different from that seen during normal ageing, which seems to affect more severely the caudate nucleus than the putamen.
Striatal dopamine reuptake sites were studied in brain samples from 14 Alzheimer's disease (AD) patients. A cocaine analogue, [3H]CFT (WIN 35,428, 2beta-carbomethoxy-3beta-(4-fluorophenyl)-tropane) was used as a radioligand to determine the number of [3H]CFT binding sites (Bmax) and their dissociation constant (Kd). In patients with AD the reduction in [3H]CFT binding in the putamen was about 50% compared to age-matched controls. In the caudate nucleus the reduction was about 33%. Thus, the putamen was more severely affected. No change was observed in Kd values between AD patients and controls. Brain samples from 37 healthy controls (aged from 8 to 91 years) were used to study the changes in striatal [3H]CFT binding with increasing age. The Bmax of [3H]CFT uptake was reduced both in the putamen and in the caudate nucleus. The average decline per decade was greater in the caudate nucleus (7.3%) than in the putamen (5.5%). In conclusion, the pattern of changes in AD is different from that seen during normal ageing, which seems to affect more severely the caudate nucleus than the putamen.
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