A1 Refereed original research article in a scientific journal
On the feasibility of recognition of nucleic acid sequences by metal-ion-carrying oligonucleotides
Authors: Taherpour S, Golubev O, Lonnberg T
Publisher: ELSEVIER SCIENCE SA
Publication year: 2016
Journal: Inorganica Chimica Acta
Journal name in source: INORGANICA CHIMICA ACTA
Journal acronym: INORG CHIM ACTA
Volume: 452
Issue: SI
First page : 43
Last page: 49
Number of pages: 7
ISSN: 0020-1693
DOI: https://doi.org/10.1016/j.ica.2016.01.025
Abstract
Metal-ion-mediated base pairing has been extensively studied in the context of DNA nanotechnology or expansion of the genetic alphabet but only recently with the aim of recognition of natural nucleic acid sequences. This review article focuses on the attempts to utilize metal-ion-carrying oligonucleotides as high-affinity probes for nucleic acids but relevant studies carried out at the monomer level are also discussed. Special emphasis is given to challenges inherent to this approach, such as the limited recognition elements of the canonical nucleobases and the scarcity of suitable metal ions in the intracellular medium. Finally, potential ways to overcome these challenges are proposed. (C) 2016 Elsevier B.V. All rights reserved.
Metal-ion-mediated base pairing has been extensively studied in the context of DNA nanotechnology or expansion of the genetic alphabet but only recently with the aim of recognition of natural nucleic acid sequences. This review article focuses on the attempts to utilize metal-ion-carrying oligonucleotides as high-affinity probes for nucleic acids but relevant studies carried out at the monomer level are also discussed. Special emphasis is given to challenges inherent to this approach, such as the limited recognition elements of the canonical nucleobases and the scarcity of suitable metal ions in the intracellular medium. Finally, potential ways to overcome these challenges are proposed. (C) 2016 Elsevier B.V. All rights reserved.
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