A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
A Functional Link between AMPK and Orexin Mediates the Effect of BMP8B on Energy Balance
Tekijät: Martins L, Seoane-Collazo P, Contreras C, Gonzalez-Garcia I, Martinez-Sanchez N, Gonzalez F, Zalvide J, Gallego R, Dieguez C, Nogueiras R, Tena-Sempere M, Lopez M
Kustantaja: CELL PRESS
Julkaisuvuosi: 2016
Lehti:: Cell Reports
Tietokannassa oleva lehden nimi: CELL REPORTS
Lehden akronyymi: CELL REP
Vuosikerta: 16
Numero: 8
Aloitussivu: 2231
Lopetussivu: 2242
Sivujen määrä: 12
ISSN: 2211-1247
DOI: https://doi.org/10.1016/j.celrep.2016.07.045
AMP-activated protein kinase (AMPK) in the ventromedial nucleus of the hypothalamus (VMH) and orexin (OX) in the lateral hypothalamic area (LHA) modulate brown adipose tissue (BAT) thermogenesis. However, whether these two molecular mechanisms act jointly or independently is unclear. Here, we show that the thermogenic effect of bone morphogenetic protein 8B (BMP8B) is mediated by the inhibition of AMPK in the VMH and the subsequent increase in OX signaling via the OX receptor 1 (OX1R). Accordingly, the thermogenic effect of BMP8B is totally absent in ox-null mice. BMP8B also induces browning of white adipose tissue (WAT), its thermogenic effect is sexually dimorphic (only observed in females), and its impact on OX expression and thermogenesis is abolished by the knockdown of glutamate vesicular transporter 2 (VGLUT2), implicating glutamatergic signaling. Overall, our data uncover a central network controlling energy homeostasis that may be of considerable relevance for obesity and metabolic disorders.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
