A1 Refereed original research article in a scientific journal
Angiotensin I-converting enzyme inhibitory and antihypertensive properties of potato and rapeseed protein-derived peptides
Authors: Makinen S, Streng T, Larsen LB, Laine A, Pihlanto A
Publisher: ELSEVIER SCIENCE BV
Publication year: 2016
Journal: Journal of Functional Foods
Journal name in source: JOURNAL OF FUNCTIONAL FOODS
Journal acronym: J FUNCT FOODS
Volume: 25
First page : 160
Last page: 173
Number of pages: 14
ISSN: 1756-4646
DOI: https://doi.org/10.1016/j.jff.2016.05.016(external)
Abstract
The angiotensin I-converting enzyme (ACE) inhibitory and antihypertensive properties of potato and rapeseed protein-derived peptides were investigated. Proteins from potato tubers were digested by autolysis and rapeseed meal proteins were hydrolysed with Alcalase. The digestions were followed by ultra filtration and solid phase extraction to concentrate the ACE inhibitory peptides. The effects of potato peptides (PP) and rapeseed peptides (RP) on blood pressure were measured in vivo in Goldblatt rat model of hypertension. The maximum difference in mean arterial pressure was approximately-60 mmHg induced by PP and 50 mmHg by RP in comparison to vehicle treated rats. Peptide analysis with LC and MS/MS showed a diverse peptide composition for the PP and RP. The results of the present study indicate first time the preventive potential of potato and rapeseed protein-derived peptides against the progression of hypertension in vivo. (C) 2016 Elsevier Ltd. All rights reserved.
The angiotensin I-converting enzyme (ACE) inhibitory and antihypertensive properties of potato and rapeseed protein-derived peptides were investigated. Proteins from potato tubers were digested by autolysis and rapeseed meal proteins were hydrolysed with Alcalase. The digestions were followed by ultra filtration and solid phase extraction to concentrate the ACE inhibitory peptides. The effects of potato peptides (PP) and rapeseed peptides (RP) on blood pressure were measured in vivo in Goldblatt rat model of hypertension. The maximum difference in mean arterial pressure was approximately-60 mmHg induced by PP and 50 mmHg by RP in comparison to vehicle treated rats. Peptide analysis with LC and MS/MS showed a diverse peptide composition for the PP and RP. The results of the present study indicate first time the preventive potential of potato and rapeseed protein-derived peptides against the progression of hypertension in vivo. (C) 2016 Elsevier Ltd. All rights reserved.
UTU Research Portal