A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
In-Vivo Bone-Targeting of Bis(phosphonate)-Conjugated Double Helical RNA Monitored by Positron Emission Tomography
Tekijät: Satish Jadhav, Meeri Käkelä, Matthieu Bourgery, Kiira Rimpilä, Heidi Liljenbäck, Riikka Siitonen, Jussi Mäkilä, Tiina Laitala-Leinonen, Päivi Poijärvi-Virta, Harri Lönnberg, Anne Roivainen, Pasi Virta
Kustantaja: AMER CHEMICAL SOC
Julkaisuvuosi: 2016
Journal: Molecular Pharmaceutics
Tietokannassa oleva lehden nimi: MOLECULAR PHARMACEUTICS
Lehden akronyymi: MOL PHARMACEUT
Vuosikerta: 13
Numero: 7
Aloitussivu: 2588
Lopetussivu: 2595
Sivujen määrä: 8
ISSN: 1543-8384
DOI: https://doi.org/10.1021/acs.molpharmaceut.6b00261
Tiivistelmä
A bis(phosphonate) conjugate of 2'-O-methyl oligoribonucleotide (microRNA-21) was synthesized and used as a bone-targeting carrier in the systemic delivery of a Ga-68-1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA)chelated 2'-O-methyl oligoribonucleotide (anti-microRNA-21). The whole-body biodistribution of the double helical RNA was monitored by positron emission tomography (PET), which verified the expected bis(phosphonate)-induced bone accumulation in healthy rats.
A bis(phosphonate) conjugate of 2'-O-methyl oligoribonucleotide (microRNA-21) was synthesized and used as a bone-targeting carrier in the systemic delivery of a Ga-68-1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA)chelated 2'-O-methyl oligoribonucleotide (anti-microRNA-21). The whole-body biodistribution of the double helical RNA was monitored by positron emission tomography (PET), which verified the expected bis(phosphonate)-induced bone accumulation in healthy rats.
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