A1 Refereed original research article in a scientific journal
Beyond MHC: signals of elevated selection pressure on Atlantic salmon (Salmo salar) immune-relevant loci
Authors: Tonteri A, Vasemagi A, Lumme J, Primmer CR
Publisher: WILEY-BLACKWELL PUBLISHING, INC
Publication year: 2010
Journal: Molecular Ecology
Journal name in source: MOLECULAR ECOLOGY
Journal acronym: MOL ECOL
Number in series: 7
Volume: 19
Issue: 7
First page : 1273
Last page: 1282
Number of pages: 10
ISSN: 0962-1083
DOI: https://doi.org/10.1111/j.1365-294X.2010.04573.x
Abstract
Using Atlantic salmon (Salmo salar) as a model system, we investigated whether 18 microsatellites tightly linked to immune-relevant genes have experienced different selection pressures than 76 loci with no obvious association with immune function. Immune-relevant loci were identified as outliers by two outlier tests significantly more often than nonimmune linked loci (22% vs. 1.6%). In addition, the allele frequencies of immune relevant markers were more often correlated with latitude and temperature. Combined, these results support the hypothesis that immune-relevant loci more frequently exhibit footprints of selection than other loci. They also indicate that the correlation between immune-relevant loci and latitude may be due to temperature-induced differences in pathogen-driven selection or some other environmental factor correlated with latitude.
Using Atlantic salmon (Salmo salar) as a model system, we investigated whether 18 microsatellites tightly linked to immune-relevant genes have experienced different selection pressures than 76 loci with no obvious association with immune function. Immune-relevant loci were identified as outliers by two outlier tests significantly more often than nonimmune linked loci (22% vs. 1.6%). In addition, the allele frequencies of immune relevant markers were more often correlated with latitude and temperature. Combined, these results support the hypothesis that immune-relevant loci more frequently exhibit footprints of selection than other loci. They also indicate that the correlation between immune-relevant loci and latitude may be due to temperature-induced differences in pathogen-driven selection or some other environmental factor correlated with latitude.
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