A1 Refereed original research article in a scientific journal

Changes in total and unbound concentrations of sufentanil during target controlled infusion for cardiac surgery with cardiopulmonary bypass



Authors: Jeleazcov C, Saari TI, Ihmsen H, Schuttler J, Fechner J

Publisher: OXFORD UNIV PRESS

Publication year: 2012

Journal: British Journal of Anaesthesia

Journal name in source: BRITISH JOURNAL OF ANAESTHESIA

Journal acronym: BRIT J ANAESTH

Volume: 109

Issue: 5

First page : 698

Last page: 706

Number of pages: 9

ISSN: 0007-0912

DOI: https://doi.org/10.1093/bja/aes253


Abstract
Neither total nor unbound sufentanil concentrations remained constant when performing a TCI with the Gepts model in coronary artery bypass surgery with CPB. A pharmacokinetic model derived from patients undergoing cardiac surgery with CPB might improve the performance of TCI in this population.



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