A1 Refereed original research article in a scientific journal
Vascular Endothelial Growth Factor-B Acts as a Coronary Growth Factor in Transgenic Rats Without Inducing Angiogenesis, Vascular Leak, or Inflammation
Authors: Bry M, Kivela R, Holopainen T, Anisimov A, Tammela T, Soronen J, Silvola J, Saraste A, Jeltsch M, Korpisalo P, Carmeliet P, Lemstrom KB, Shibuya M, Yla-Herttuala S, Alhonen L, Mervaala E, Andersson LC, Knuuti J, Alitalo K
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Publication year: 2010
Journal: Circulation
Journal name in source: CIRCULATION
Journal acronym: CIRCULATION
Number in series: 17
Volume: 122
Issue: 17
First page : 1725
Last page: 1733
Number of pages: 9
ISSN: 0009-7322
DOI: https://doi.org/10.1161/CIRCULATIONAHA.110.957332
Abstract
Conclusions-VEGF-B appears to be a coronary growth factor in rats but not in mice. The signals for the VEGF-B-induced cardiac hypertrophy are mediated at least in part via the endothelium. Because cardiomyocyte damage in myocardial ischemia begins in the subendocardial myocardium, the VEGF-B-induced increased arterial supply to this area could have therapeutic potential in ischemic heart disease. (Circulation. 2010;122:1725-1733.)
Conclusions-VEGF-B appears to be a coronary growth factor in rats but not in mice. The signals for the VEGF-B-induced cardiac hypertrophy are mediated at least in part via the endothelium. Because cardiomyocyte damage in myocardial ischemia begins in the subendocardial myocardium, the VEGF-B-induced increased arterial supply to this area could have therapeutic potential in ischemic heart disease. (Circulation. 2010;122:1725-1733.)
UTU Research Portal