A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Parental Age and Risk of Autism Spectrum Disorders in a Finnish National Birth Cohort
Tekijät: Lampi KM, Hinkka-Yli-Salomaki S, Lehti V, Helenius H, Gissler M, Brown AS, Sourander A
Kustantaja: SPRINGER/PLENUM PUBLISHERS
Julkaisuvuosi: 2013
Journal: Journal of Autism and Developmental Disorders
Tietokannassa oleva lehden nimi: JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
Lehden akronyymi: J AUTISM DEV DISORD
Numero sarjassa: 11
Vuosikerta: 43
Numero: 11
Aloitussivu: 2526
Lopetussivu: 2535
Sivujen määrä: 10
ISSN: 0162-3257
DOI: https://doi.org/10.1007/s10803-013-1801-3
Tiivistelmä
Aim of the study was to examine the associations between parental age and autism spectrum disorders (ASD). Data were based on the FIPS-A (Finnish Prenatal Study of Autism and Autism Spectrum Disorders), a case-control study with a total of 4,713 cases with childhood autism (n = 1,132), Asperger's syndrome (n = 1,785) or other pervasive developmental disorder (PDD) (n = 1,796), which were ascertained from the Finnish Hospital Discharge Register. Controls were selected from the Finnish Medical Birth Register. Conditional logistic regression models were used for statistical analyses. Advanced paternal age (35-49 years) was associated with childhood autism in offspring, whereas advanced maternal age was associated with both Asperger's syndrome and PDD in offspring (35 years or more and 40 years or more, respectively). Teenage motherhood (19 years or less) was associated with PDD in offspring. The main finding was that maternal and paternal ages were differentially associated with ASD subtypes. In addition to advanced parental age, teenage pregnancy seems to incur a risk for PDD in offspring.
Aim of the study was to examine the associations between parental age and autism spectrum disorders (ASD). Data were based on the FIPS-A (Finnish Prenatal Study of Autism and Autism Spectrum Disorders), a case-control study with a total of 4,713 cases with childhood autism (n = 1,132), Asperger's syndrome (n = 1,785) or other pervasive developmental disorder (PDD) (n = 1,796), which were ascertained from the Finnish Hospital Discharge Register. Controls were selected from the Finnish Medical Birth Register. Conditional logistic regression models were used for statistical analyses. Advanced paternal age (35-49 years) was associated with childhood autism in offspring, whereas advanced maternal age was associated with both Asperger's syndrome and PDD in offspring (35 years or more and 40 years or more, respectively). Teenage motherhood (19 years or less) was associated with PDD in offspring. The main finding was that maternal and paternal ages were differentially associated with ASD subtypes. In addition to advanced parental age, teenage pregnancy seems to incur a risk for PDD in offspring.
Turun yliopiston Tutkimustietojärjestelmän portaali