A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
Role of lectin microarrays in cancer diagnosis
Tekijät: Parvez Syed, Kamlesh Gidwani, Henna Kekki, Janne Leivo, Kim Pettersson, Urpo Lamminmäki
Kustantaja: WILEY-BLACKWELL
Julkaisuvuosi: 2016
Journal: Proteomics
Tietokannassa oleva lehden nimi: PROTEOMICS
Lehden akronyymi: PROTEOMICS
Vuosikerta: 16
Numero: 8
Aloitussivu: 1257
Lopetussivu: 1265
Sivujen määrä: 9
ISSN: 1615-9853
eISSN: 1615-9861
DOI: https://doi.org/10.1002/pmic.201500404
Tiivistelmä
The majority of cell differentiation associated tumor markers reported to date are either glycoproteins or glycolipids. Despite there being a large number of glycoproteins reported as candidate markers for various cancers, only a handful are approved by the US Food and Drug Administration. Lectins, which bind to the glycan part of the glycoproteins, can be exploited to identify aberrant glycosylation patterns, which in turn would help in enhancing the specificity of cancer diagnosis. Although conventional techniques such as HPLC and MS have been instrumental in performing the glycomic analyses, these techniques lack multiplexity. Lectin microarrays have proved to be useful in studying multiple lectin-glycan interactions in a single experiment and, with the advances made in the field, hold a promise of enabling glycomic profiling of cancers in a fast and efficient manner.
The majority of cell differentiation associated tumor markers reported to date are either glycoproteins or glycolipids. Despite there being a large number of glycoproteins reported as candidate markers for various cancers, only a handful are approved by the US Food and Drug Administration. Lectins, which bind to the glycan part of the glycoproteins, can be exploited to identify aberrant glycosylation patterns, which in turn would help in enhancing the specificity of cancer diagnosis. Although conventional techniques such as HPLC and MS have been instrumental in performing the glycomic analyses, these techniques lack multiplexity. Lectin microarrays have proved to be useful in studying multiple lectin-glycan interactions in a single experiment and, with the advances made in the field, hold a promise of enabling glycomic profiling of cancers in a fast and efficient manner.
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