Plasma osteopontin is not associated with vascular markers of subclinical atherosclerosis in a population of young adults without symptoms of cardiovascular disease. The Cardiovascular Risk in Young Finns Study



: Wendelin-Saarenhovi M, Oikonen M, Loo BM, Juonala M, Kahonen M, Viikari JSA, Raitakari OT

Publisher: INFORMA HEALTHCARE

: 2011

: Scandinavian Journal of Clinical and Laboratory Investigation

: SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

: SCAND J CLIN LAB INV

: 8

: 71

: 8

: 683

: 689

: 7

: 0036-5513

DOI: https://doi.org/10.3109/00365513.2011.621027


Objective: Osteopontin is used as a biomarker for measuring the severity of atherosclerosis, but the role of osteopontin in the pathogenesis of atherosclerosis is not clear. Methods: The distribution and determinants of osteopontin were studied in a randomized cohort of 1,817 young adults (aged 30-45 years) without clinical symptoms of atherosclerosis. Results: The mean +/- SD osteopontin concentration was 60.7 +/- 15.6 mu g/mL in men and 51.7 +/- 16.0 mu g/mL in women. In multi-variable models the correlates of osteopontin explained 6.9% (Model R(2)) of the total variation in osteopontin in men, including CRP (beta = 3.02, p < 0.0001), SHBG (beta = 0.21, p < 0.0001), total cholesterol (beta = -1.78, p = 0.002), age (beta = -0.26, p = 0.02) and alcohol use (beta = 0.57, p = 0.04) and of these CRP had the greatest influence (Partial R(2) = 2.1%). In women, multivariable correlates of osteopontin included CRP (beta = 2.90, p < 0.0001), total cholesterol (beta = -1.99, p = 0.002), insulin (beta = -1.76, p = 0.001), physical activity (beta = 0.66, p = 0.03), adiponectin (beta = 0.25, p = 0.008) and diastolic blood pressure (beta = 0.14, p = 0.003). These five variables explained 6.7% (Model R(2)) of the total variation in osteopontin, with CRP (Partial R(2) = 2.7%) having the greatest influence. Osteopontin was not associated with carotid intima-media thickness, carotid elasticity, brachial endothelial function or the presence of a carotid plaque in either sex. Conclusion: We found no evidence of association between osteopontin levels and early vascular markers of atherosclerosis in asymptomatic young adults, suggesting that osteopontin is not implicated in the preclinical atherosclerotic changes in vascular structure and function.



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