A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Mesolimbic dopamine release is linked to symptom severity in pathological gambling
Tekijät: Joutsa J, Johansson J, Niemela S, Ollikainen A, Hirvonen MM, Piepponen P, Arponen E, Alho H, Voon V, Rinne JO, Hietala J, Kaasinen V
Kustantaja: ACADEMIC PRESS INC ELSEVIER SCIENCE
Julkaisuvuosi: 2012
Journal: NeuroImage
Tietokannassa oleva lehden nimi: NEUROIMAGE
Lehden akronyymi: NEUROIMAGE
Numero sarjassa: 4
Vuosikerta: 60
Numero: 4
Aloitussivu: 1992
Lopetussivu: 1999
Sivujen määrä: 8
ISSN: 1053-8119
DOI: https://doi.org/10.1016/j.neuroimage.2012.02.006
Tiivistelmä
Conclusions: Striatal dopamine is released during gambling irrespective of gambling outcome suggesting that the mere expectation/prediction of reward is sufficient to induce dopaminergic changes. Although dopamine release during slot machine gambling is comparable between healthy controls and pathological gamblers, greater gambling symptom severity is associated with greater dopaminergic responses. Thus, as the dopamine reward deficiency theory predicts blunted mesolimbic dopamine responses to gambling in addicted individuals, our results question the validity of the reward deficiency hypothesis in pathological gambling. (C) 2012 Elsevier Inc. All rights reserved.
Conclusions: Striatal dopamine is released during gambling irrespective of gambling outcome suggesting that the mere expectation/prediction of reward is sufficient to induce dopaminergic changes. Although dopamine release during slot machine gambling is comparable between healthy controls and pathological gamblers, greater gambling symptom severity is associated with greater dopaminergic responses. Thus, as the dopamine reward deficiency theory predicts blunted mesolimbic dopamine responses to gambling in addicted individuals, our results question the validity of the reward deficiency hypothesis in pathological gambling. (C) 2012 Elsevier Inc. All rights reserved.
Turun yliopiston Tutkimustietojärjestelmän portaali