A1 Refereed original research article in a scientific journal
Phenolic Compounds from Eucalyptus gomphocephala with Potential Cytotoxic and Antioxidant Activities
Authors: Al-Sayed E, Martiskainen O, Bobrowska-Hagerstrand M, Sinkkonen J, Tornquist K, Pihlaja K, Ayoub N, Singab AN
Publisher: NATURAL PRODUCTS INC
Publication year: 2010
Journal: Natural Product Communications
Journal name in source: NATURAL PRODUCT COMMUNICATIONS
Journal acronym: NAT PROD COMMUN
Number in series: 10
Volume: 5
Issue: 10
First page : 1639
Last page: 1642
Number of pages: 4
ISSN: 1934-578X
Abstract
Two new phenolic compounds, 2,4,6-trihydroxy-5-methyl-acetophenone 2-O-beta-D-glucopyranoside (3), and benzyl alcohol 7-O-(3',4',6'-tri-O-galloyl)-beta-D-glucopyranoside (8), together with eight known phenolic compounds, were isolated from the 70% aqueous acetone extract of Eucalyptus gomphocephala DC. (Myrtaceae). The isolated compounds were elucidated based on their (1)H, (13)C, DQF-COSY, selective 1D-TOCSY, HSQC, and HMBC NMR spectroscopic and ESI-MS data. The antioxidant effect of the phenolic compounds was tested using 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydroxyl radical and super oxide anion radical scavenging assays. The cytotoxicity of the isolated compounds was evaluated using HeLa cell line.
Two new phenolic compounds, 2,4,6-trihydroxy-5-methyl-acetophenone 2-O-beta-D-glucopyranoside (3), and benzyl alcohol 7-O-(3',4',6'-tri-O-galloyl)-beta-D-glucopyranoside (8), together with eight known phenolic compounds, were isolated from the 70% aqueous acetone extract of Eucalyptus gomphocephala DC. (Myrtaceae). The isolated compounds were elucidated based on their (1)H, (13)C, DQF-COSY, selective 1D-TOCSY, HSQC, and HMBC NMR spectroscopic and ESI-MS data. The antioxidant effect of the phenolic compounds was tested using 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydroxyl radical and super oxide anion radical scavenging assays. The cytotoxicity of the isolated compounds was evaluated using HeLa cell line.
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