Activation of indoleamine 2,3-dioxygenase-induced tryptophan degradation in advanced atherosclerotic plaques: Tampere Vascular Study - UTU Research Portal

A1 Refereed original research article in a scientific journal

Activation of indoleamine 2,3-dioxygenase-induced tryptophan degradation in advanced atherosclerotic plaques: Tampere Vascular Study

Authors: Niinisalo P, Oksala N, Levula M, Pelto-Huikko M, Jarvinen O, Salenius JP, Kytomaki L, Soini JT, Kahonen M, Laaksonen R, Hurme M, Lehtimaki T

Publisher: INFORMA HEALTHCARE

Publication year: 2010

Journal: Annals of Medicine

Journal name in source: ANNALS OF MEDICINE

Journal acronym: ANN MED

Number in series: 1

Volume: 42

Issue: 1

First page : 55

Last page: 63

Number of pages: 9

ISSN: 0785-3890

DOI: https://doi.org/10.3109/07853890903321559

Abstract

Conclusions. IDO and the IDO-related pathway are important mediators of the immunoinflammatory responses in advanced atherosclerosis offering new viable therapeutic targets for the development of antiatherogenic immunosuppressive therapies.