Peptide and protein imaging mass spectrometry in cancer research - UTU Research Portal

A1 Refereed original research article in a scientific journal

Peptide and protein imaging mass spectrometry in cancer research

Authors: McDonnell LA, Corthals GL, Willems SM, van Remoortere A, van Zeijl RJM, Deelder AM

Publisher: ELSEVIER SCIENCE BV

Publication year: 2010

Journal: Journal of Proteomics

Journal name in source: JOURNAL OF PROTEOMICS

Journal acronym: J PROTEOMICS

Number in series: 10

Volume: 73

Issue: 10

First page : 1921

Last page: 1944

Number of pages: 24

ISSN: 1874-3919

DOI: https://doi.org/10.1016/j.jprot.2010.05.007

Abstract

Here the latest methodological developments are summarized and its application to a range of tumors is reported in detail. The prospects of MALDI imaging MS are then described from the perspectives of modern pathological practice and MS-based proteomics, to ensure the outlook addresses real clinical needs and reflects the real capabilities of MS-based proteomics of complex tissue samples. (C) 2010 Elsevier B.V. All rights reserved.