Inhibition of receptor tyrosine kinase signalling by small molecule agonist of T-cell protein tyrosine phosphatase - UTU Research Portal

A1 Refereed original research article in a scientific journal

Inhibition of receptor tyrosine kinase signalling by small molecule agonist of T-cell protein tyrosine phosphatase

Authors: Mattila E, Marttila H, Sahlberg N, Kohonen P, Tahtinen S, Halonen P, Perala M, Ivaska J

Publisher: BIOMED CENTRAL LTD

Publication year: 2010

Journal: BMC Cancer

Journal name in source: BMC CANCER

Journal acronym: BMC CANCER

Number in series: 7

Volume: 10

Issue: 7

Number of pages: 12

ISSN: 1471-2407

DOI: https://doi.org/10.1186/1471-2407-10-7

Abstract

Conclusions: In this study we showed that small molecules mimicking TCPTP-alpha 1 interaction can be used as TCPTP agonists. These data provide the first proof-of-concept description of the use of high-throughput screening to identify small molecule PTP activators that could function as RTK antagonists in cells.