A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Association of CTLA4 but not ICOS polymorphisms with type 1 diabetes in two populations with different disease rates
Tekijät: Douroudis K, Laine AP, Heinonen M, Hermann R, Lipponen K, Veijola R, Simell O, Knip M, Uibo R, Ilonen J, Kisand K
Kustantaja: ELSEVIER SCIENCE INC
Julkaisuvuosi: 2009
Journal: Human Immunology
Tietokannassa oleva lehden nimi: HUMAN IMMUNOLOGY
Lehden akronyymi: HUM IMMUNOL
Vuosikerta: 70
Numero: 7
Aloitussivu: 536
Lopetussivu: 539
Sivujen määrä: 4
ISSN: 0198-8859
DOI: https://doi.org/10.1016/j.humimm.2009.04.023
Tiivistelmä
Cytotoxic T lymphocyte-associated protein 4 (CTLA-4) and inducible T-cell co-stimulator (ICOS) genes are important mediators off-cell activation in autoimmune diseases. The aim of the current study was to assess the impact of CTLA-4 and ICOS genes on the susceptibility to type I diabetes among two populations with different disease incidence rates. Three single nucleotide polymorphisms (SNPs) within the CTLA-4 region (+49A/G, CT60A/G, CrBC217_1C/T) and two SNPs within the ICOS region (CTIC154_1C/T, CTIC159 C/G) were genotyped in 955 control subjects and 574 diabetic patients of Estonian and Finnish descent. The current study confirms the involvement of the CTLA-4 but not the ICOS gene in susceptibility to type I diabetes. However, the risk alleles and the defined main risk haplotype were more common in the Finnish controls compared with the Estonians, indicating that this gene locus might also be one of the contributing factors to the higher disease incidence in Finland. (C) 2009 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
Cytotoxic T lymphocyte-associated protein 4 (CTLA-4) and inducible T-cell co-stimulator (ICOS) genes are important mediators off-cell activation in autoimmune diseases. The aim of the current study was to assess the impact of CTLA-4 and ICOS genes on the susceptibility to type I diabetes among two populations with different disease incidence rates. Three single nucleotide polymorphisms (SNPs) within the CTLA-4 region (+49A/G, CT60A/G, CrBC217_1C/T) and two SNPs within the ICOS region (CTIC154_1C/T, CTIC159 C/G) were genotyped in 955 control subjects and 574 diabetic patients of Estonian and Finnish descent. The current study confirms the involvement of the CTLA-4 but not the ICOS gene in susceptibility to type I diabetes. However, the risk alleles and the defined main risk haplotype were more common in the Finnish controls compared with the Estonians, indicating that this gene locus might also be one of the contributing factors to the higher disease incidence in Finland. (C) 2009 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
Turun yliopiston Tutkimustietojärjestelmän portaali