A1 Refereed original research article in a scientific journal
Dps-like proteins: structural and functional insights into a versatile protein family
Authors: Haikarainen T, Papageorgiou AC
Publisher: BIRKHAUSER VERLAG AG
Publication year: 2010
Journal: Cellular and Molecular Life Sciences
Journal name in source: CELLULAR AND MOLECULAR LIFE SCIENCES
Journal acronym: CELL MOL LIFE SCI
Volume: 67
Issue: 3
First page : 341
Last page: 351
Number of pages: 11
ISSN: 1420-682X
DOI: https://doi.org/10.1007/s00018-009-0168-2
Abstract
Dps-like proteins are key factors involved in the protection of prokaryotic cells from oxidative damage. They act by either oxidizing iron to prevent the formation of oxidative radicals or by forming Dps-DNA complexes to physically protect DNA. All Dps-like proteins are characterized by a common three-dimensional architecture and are found as spherical dodecamers with a hollow central cavity. Despite their structural similarities, recent biochemical and structural data have suggested different functions among members of the family that range from protection inside the cells in response to various stress signals to adhesion and virulence during bacterial infections. Moreover, the Dps-like proteins have lately attracted considerable interest in the field of nanotechnology owing to their ability to act as protein cages for iron and various other metals. A better understanding of their function and mechanism could therefore lead to novel applications in biotechnology and nanotechnology.
Dps-like proteins are key factors involved in the protection of prokaryotic cells from oxidative damage. They act by either oxidizing iron to prevent the formation of oxidative radicals or by forming Dps-DNA complexes to physically protect DNA. All Dps-like proteins are characterized by a common three-dimensional architecture and are found as spherical dodecamers with a hollow central cavity. Despite their structural similarities, recent biochemical and structural data have suggested different functions among members of the family that range from protection inside the cells in response to various stress signals to adhesion and virulence during bacterial infections. Moreover, the Dps-like proteins have lately attracted considerable interest in the field of nanotechnology owing to their ability to act as protein cages for iron and various other metals. A better understanding of their function and mechanism could therefore lead to novel applications in biotechnology and nanotechnology.
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