Human biodistribution and radiation dosimetry of C-11-(R)-PK11195, the prototypic PET ligand to image inflammation

: Hirvonen J, Roivainen A, Virta J, Helin S, Nagren K, Rinne JO

Publisher: SPRINGER

: 2010

: European Journal of Nuclear Medicine and Molecular Imaging

: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

: EUR J NUCL MED MOL I

: 3

: 37

: 3

: 606

: 612

: 7

: 1619-7070

DOI: https://doi.org/10.1007/s00259-009-1298-3(external)

Imaging of TSPO with PET using C-11-(R)-PK11195 is associated with modest radiation exposure, similar in magnitude to most other C-11-labelled PET tracers, suggesting feasibility of C-11-(R)-PK11195 imaging in clinical human studies involving multiple scans in the same subjects per year.