A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
Oxime formation for fluorine-18 labeling of peptides and proteins for positron emission tomography (PET) imaging: A review
Tekijät: Li XG, Haaparanta M, Solin O
Kustantaja: ELSEVIER SCIENCE SA
Julkaisuvuosi: 2012
Journal: Journal of Fluorine Chemistry
Tietokannassa oleva lehden nimi: JOURNAL OF FLUORINE CHEMISTRY
Lehden akronyymi: J FLUORINE CHEM
Vuosikerta: 143
Aloitussivu: 49
Lopetussivu: 56
Sivujen määrä: 8
ISSN: 0022-1139
DOI: https://doi.org/10.1016/j.jfluchem.2012.07.005
Tiivistelmä
Positron emission tomography (PET) is a powerful technology for medical and biological imaging and the scope of PET applications is expanding rapidly. The development of suitable PET tracers is at a central position in PET technology. An increasing number of peptides and proteins have been developed for the clinic due to their special properties which small molecule drugs do not have. These advances have provoked interest in the research community to develop radiolabeled peptides and proteins for diagnosis and therapy. Fluorine-18 is a short-lived isotope of fluorine with superior properties for PET-imaging. A majority of presently used radiopharmaceuticals in PET are labeled with fluorine-18. This review focuses on a promising strategy, oxime formation of aminooxy-functionalized peptides with F-18-containing aldehydes, for fluorine-18 labeling of peptides/proteins. At present only a few F-18-containing prosthetic groups are available for oxime formation. The radiosynthesis of the F-18-containing aldehydes and key factors influencing conjugation efficiency of F-18-containing aldehydes with peptides are addressed. (C) 2012 Elsevier B.V. All rights reserved.
Positron emission tomography (PET) is a powerful technology for medical and biological imaging and the scope of PET applications is expanding rapidly. The development of suitable PET tracers is at a central position in PET technology. An increasing number of peptides and proteins have been developed for the clinic due to their special properties which small molecule drugs do not have. These advances have provoked interest in the research community to develop radiolabeled peptides and proteins for diagnosis and therapy. Fluorine-18 is a short-lived isotope of fluorine with superior properties for PET-imaging. A majority of presently used radiopharmaceuticals in PET are labeled with fluorine-18. This review focuses on a promising strategy, oxime formation of aminooxy-functionalized peptides with F-18-containing aldehydes, for fluorine-18 labeling of peptides/proteins. At present only a few F-18-containing prosthetic groups are available for oxime formation. The radiosynthesis of the F-18-containing aldehydes and key factors influencing conjugation efficiency of F-18-containing aldehydes with peptides are addressed. (C) 2012 Elsevier B.V. All rights reserved.
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