Sex hormone-binding globulin associations with circulating lipids and metabolites and the risk for type 2 diabetes: observational and causal effect estimates



: Wang Q, Kangas AJ, Soininen P, Tiainen M, Tynkkynen T, Puukka K, Ruokonen A, Viikari J, Kahonen M, Lehtimaki T, Salomaa V, Perola M, Smith GD, Raitakari OT, Jarvelin MR, Wurtz P, Kettunen J, Ala-Korpela M

Publisher: OXFORD UNIV PRESS

: 2015

 International Journal of Epidemiology

: INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

: INT J EPIDEMIOL

: 44

: 2

: 623

: 637

: 15

: 0300-5771

: 1464-3685

DOI: https://doi.org/10.1093/ije/dyv093


Conclusion: Circulating SHBG is strongly associated with systemic metabolism and predictive for insulin resistance and diabetes. The weaker causal estimates suggest that the observational associations are partly confounded rather than conferred directly via circulating SHBG.




Last updated on 26/11/2024 11:22:45 PM