How Much Oxycodone Is Needed for Adequate Analgesia After Breast Cancer Surgery: Effect of the OPRM1 118A>G Polymorphism - UTU Research Portal

A1 Refereed original research article in a scientific journal

How Much Oxycodone Is Needed for Adequate Analgesia After Breast Cancer Surgery: Effect of the OPRM1 118A>G Polymorphism

Authors: Cajanus K, Kaunisto MA, Tallgren M, Jokela R, Kalso E

Publisher: CHURCHILL LIVINGSTONE

Publication year: 2014

Journal: Journal of Pain

Journal name in source: JOURNAL OF PAIN

Journal acronym: J PAIN

Volume: 15

Issue: 12

First page : 1248

Last page: 1256

Number of pages: 9

ISSN: 1526-5900

DOI: https://doi.org/10.1016/j.jpain.2014.09.002(external)

Abstract

Perspective: This study demonstrates that the OPRM1 118A>G polymorphism was associated with the amount of oxycodorie required in the immediate postoperative period. Although a significant factor for determining oxycodone requirement, the 118A>G polymorphism alone explained less than 1% of the variance. No association was found between 118A>G and experimental pain. (C) 2014 by the American Pain Society