A1 Refereed original research article in a scientific journal
LINKAGE DISEQUILIBRIUM UTILIZED TO ESTABLISH A REFINED GENETIC POSITION OF THE SALLA DISEASE LOCUS ON 6Q14-Q15
Authors: SCHLEUTKER J, LAINE AP, HAATAJA L, RENLUND M, WEISSENBACH J, AULA P, PELTONEN L
Publisher: ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS
Publication year: 1995
Journal: Genomics
Journal name in source: GENOMICS
Journal acronym: GENOMICS
Volume: 27
Issue: 2
First page : 286
Last page: 292
Number of pages: 7
ISSN: 0888-7543
DOI: https://doi.org/10.1006/geno.1995.1044(external)
Abstract
Salla disease (SD), an inherited free sialic acid storage disorder, is caused by impaired transport of free sialic acid across the lysosomal membrane. Clinical characteristics of the disease include severe psychomotor retardation and some neurological abnormalities. We report here detailed linkage analyses of 50 Finnish SD families that localize the SD disease gene to a refined chromosomal area on 6q14-q15. The highest led score of 17.30 was obtained with a microsatellite marker of locus D6S280. When linkage disequilibrium was adopted in the linkage analyses, we could further assign the SD locus to the immediate vicinity of marker locus D6S406. Linkage disequilibrium facilitated further restriction of the critical chromosomal region to approximately 80 kb, well within the limits of positional cloning techniques. (C) 1995 Academic Press, Inc.
Salla disease (SD), an inherited free sialic acid storage disorder, is caused by impaired transport of free sialic acid across the lysosomal membrane. Clinical characteristics of the disease include severe psychomotor retardation and some neurological abnormalities. We report here detailed linkage analyses of 50 Finnish SD families that localize the SD disease gene to a refined chromosomal area on 6q14-q15. The highest led score of 17.30 was obtained with a microsatellite marker of locus D6S280. When linkage disequilibrium was adopted in the linkage analyses, we could further assign the SD locus to the immediate vicinity of marker locus D6S406. Linkage disequilibrium facilitated further restriction of the critical chromosomal region to approximately 80 kb, well within the limits of positional cloning techniques. (C) 1995 Academic Press, Inc.
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