Blood microRNA profile associates with the levels of serum lipids and metabolites associated with glucose metabolism and insulin resistance and pinpoints pathways underlying metabolic syndrome The cardiovascular risk in Young Finns Study

: Raitoharju E, Seppala I, Oksala N, Lyytikainen LP, Raitakari O, Viikari J, Ala-Korpela M, Soininen P, Kangas AJ, Waldenberger M, Klopp N, Illig T, Leiviska J, Loo BM, Hutri-Kahonen N, Kahonen M, Laaksonen R, Lehtimaki T

Publisher: ELSEVIER IRELAND LTD

: 2014

: Molecular and Cellular Endocrinology

: MOLECULAR AND CELLULAR ENDOCRINOLOGY

: MOL CELL ENDOCRINOL

: 391

: 11

: 41

: 49

: 9

: 0303-7207

DOI: https://doi.org/10.1016/j.mce.2014.04.013

We found nine microRNAs that associated significantly with metabolites connected to MetS. MicroRNA-144-5p concentration correlated with glucose levels, hsa-1207-5p with glycosylated hemoglobin and hsa-miR-484 with metabolites related to insulin resistance. Hsa-miR-625-3p correlated with cholesterol levels, hsa-miR-1237-3p and hsa-miR-331-3p expression with certain fatty acids levels and hsa-miR-129-1-3p, -129-2-3p, and -1288-3p with glycerol levels. The down-regulated targets of miR-1207-5p and -129-2-3p were enriched in PI3K and MAPK pathways and 8 out of the 12 enriched pathways were down-regulated in individuals with MetS. In conclusion microRNAs associated with several aspects of MetS, possibly regulating glucose and lipid metabolism. (C) 2014 Elsevier Ireland Ltd. All rights reserved.