A1 Refereed original research article in a scientific journal

Translating the concept of peptide labeling with 5-deoxy-5-[F-18] fluororibose into preclinical practice: F-18-labeling of Siglec-9 peptide for PET imaging of inflammation



Authors: Li XG, Autio A, Ahtinen H, Helariutta K, Liljenback H, Jalkanen S, Roivainen A, Airaksinen AJ

Publisher: ROYAL SOC CHEMISTRY

Publication year: 2013

Journal: Chemical Communications

Journal name in source: CHEMICAL COMMUNICATIONS

Journal acronym: CHEM COMMUN

Number in series: 35

Volume: 49

Issue: 35

First page : 3682

Last page: 3684

Number of pages: 3

ISSN: 1359-7345

DOI: https://doi.org/10.1039/c3cc40738a


Abstract
Peptide glycosylation with 5-deoxy-5-[F-18]fluororibose was translated into preclinical settings. The novel F-18-labeled Siglec-9 peptide was produced using an automated synthesis procedure. The F-18-labeled Siglec-9 peptide showed favorable binding in the animal model of inflammation in vivo.



Last updated on 2024-26-11 at 15:21