Somatostatin receptor subtype 2 in high-grade gliomas: PET/CT with Ga-68-DOTA-peptides, correlation to prognostic markers, and implications for targeted radiotherapy



: Aida Kiviniemi, Maria Gardberg, Janek Frantzén, Marko Pesola, Ville Vuorinen, Riitta Parkkola, Tuula Tolvanen, Sami Suilamo, Jarkko Johansson, Pauliina Luoto, Jukka Kemppainen, Anne Roivainen, Heikki Minn

Publisher: SPRINGER HEIDELBERG

: 2015

: EJNMMI Research

: EJNMMI RESEARCH

: EJNMMI RES

: ARTN 25

: 5

: 10

: 2191-219X

DOI: https://doi.org/10.1186/s13550-015-0106-2


Conclusions: In HGGs, uptake of Ga-68-DOTA-peptides is associated with disrupted BBB and cannot be predicted by SSTR2 immunohistochemistry. Thus, PET/CT shows limited value to detect HGGs suitable for PRRT. However, high SSTR2 expression portends favorable outcome along with established biomarkers such as IDH1 mutation.




Last updated on 2024-26-11 at 11:06