B1 Non-refereed article in a scientific journal
Sequence-selective cleavage of oligoribonucleotides
Authors: Niittymaki T, Lonnberg H
Publication year: 2005
Journal:: Collection Symposium Series
Journal name in source: Chemistry of Nucleic Acid Components
Journal acronym: COLL SYMPOS SERIES
Volume: 7
First page : 443
Last page: 444
Number of pages: 2
ISBN: 80-86241-25-4
Abstract
2'-O-Methyl oligoribonucleotides bearing a 1,5,9-triazacyclododec-3-yl group tethered either to the 3'-terminus of an oligonucleotide or to an intrachain abasic sugar unit have been shown to cleave in slight excess of Zn2+, ions complementary oligoribonucleotides. The cleavage obeys first-order kinetics and exhibits turnover. The accelaration compared to the monomeric Zn2+ 1,5,9-triazacyclododecane chelate is more than 100-fold for the 3'-tethered conjugates and approximately 50-fold for the intrachain conjugates.
2'-O-Methyl oligoribonucleotides bearing a 1,5,9-triazacyclododec-3-yl group tethered either to the 3'-terminus of an oligonucleotide or to an intrachain abasic sugar unit have been shown to cleave in slight excess of Zn2+, ions complementary oligoribonucleotides. The cleavage obeys first-order kinetics and exhibits turnover. The accelaration compared to the monomeric Zn2+ 1,5,9-triazacyclododecane chelate is more than 100-fold for the 3'-tethered conjugates and approximately 50-fold for the intrachain conjugates.
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