B1 Vertaisarvioimaton kirjoitus tieteellisessä lehdessä
Genetic variants within the serotonin transporter associated with familial risk for major depression
Tekijät: Ardesheer Talati, Guia Guffanti, Zagaa Odgerel, Iuliana Ionita-Laza, Heli Malm, Andre Sourander, Alan S.Browna, Priya J. Wickramaratne, Jay A.Gingrich, Myrna M.Weissman
Kustantaja: Elsevier Ireland Ltd.
Julkaisuvuosi: 2015
Journal: Psychiatry Research
Vuosikerta: 228
Numero: 1
Aloitussivu: 170
Lopetussivu: 173
Sivujen määrä: 4
ISSN: 0165-1781
DOI: https://doi.org/10.1016/j.psychres.2015.04.015
The role of the serotonin transporter promoter linked polymorphism (5HTTLPR) in depression, despite much research, remains unclear. Most studies compare persons with and without depression to each other. We show offspring at high (N=192) as compared to low (N=101) familial risk for major depressive disorder were almost four times as likely to have two copies of the short allele at 5HTTLPR, suggesting that incorporation of family history could be helpful in identifying genetic differences.
