A1 Refereed original research article in a scientific journal
Methods, quality control and specimen management in an international multicentre investigation of type 1 diabetes: TEDDY
Authors: Vehik K, Fiske SW, Logan CA, Agardh D, Cilio CM, Hagopian W, Simell O, Roivainen M, She JX, Briese T, Oikarinen S, Hyoty H, Ziegler AG, Rewers M, Lernmark A, Akolkar B, Krischer JP, Burkhardt BR, The TEDDY Study Group
Publisher: WILEY-BLACKWELL
Publication year: 2013
Journal: Diabetes/Metabolism Research and Reviews
Journal name in source: DIABETES-METABOLISM RESEARCH AND REVIEWS
Journal acronym: DIABETES-METAB RES
Number in series: 7
Volume: 29
Issue: 7
First page : 557
Last page: 567
Number of pages: 11
ISSN: 1520-7560
DOI: https://doi.org/10.1002/dmrr.2427
ConclusionsDetailed procedures were utilized to standardize both data harmonization and management when handling a large quantity of longitudinal samples obtained from multiple locations. In addition, a description of the available specimens is provided that serve as an invaluable repository for the elucidation of determinants in T1D focusing on autoantibody concordance and harmonization, transglutaminase autoantibody, inflammatory biomarkers (T-cells), genetic proficiency testing, RNA lab internal quality control testing, infectious agents (monitoring cross-contamination, virus preservation and nasal swab collection validity) and HbA(1c) testing. Copyright (c) 2013 John Wiley & Sons, Ltd.
