A1 Refereed original research article in a scientific journal
Determining optimal noninvasive parameters for the prediction of left ventricular remodeling in chronic ischemic patients
Authors: Rademakers F, Engvall J, Edvardsen T, Monaghan M, Sicari R, Nagel E, Zamorano J, Ukkonen H, Ebbers T, Di Bello V, Voigt J, Herbots L, Claus P, D'Hooge J
Publisher: INFORMA HEALTHCARE
Publishing place: LONDON; TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
Publication year: 2013
Journal: Scandinavian Cardiovascular Journal
Journal name in source: Scandinavian Cardiovascular Journal
Journal acronym: Scand.Cardiovasc.J.
Number in series: 6
Volume: 47
Issue: 6
First page : 329
Last page: 334
Number of pages: 6
ISSN: 1401-7431
DOI: https://doi.org/10.3109/14017431.2013.857039
Objectives. DOPPLER-CIP aims to determine the optimal noninvasive parameters (myocardial function, perfusion, ventricular blood flow, cell integrity) and methodology (ergometry, echocardiography, scintigraphy, MRI) in a given ischemic substrate that best predicts the impact of an intervention (or the lack thereof) on adverse morphological ventricular remodeling and functional recovery. Moreover, the relative predictive value of each of these parameters, in respect to the cost of extracting this information in order to enable optimization of cost-effectiveness for improved health care, will be determined by this project. Design. DOPPLER-CIP is a multi-center registry study. All patients with ischemic heart disease included in this study undergo at least two noninvasive stress imaging examinations at baseline. The presence/or absence of left ventricular (LV) remodeling will be assessed after a follow-up of 2 years, during which all cardiac events will be registered. Results. 676 patients were included. Currently, baseline data analysis is almost finished and the follow-up is ongoing. Conclusions. After completion, DOPPLER-CIP will provide evidence-based guidelines toward the most effective use of cardiac imaging in the chronically ischemic heart disease patient. The study will generate information, knowledge, and insight into the new imaging methodologies and into the pathophysiology of chronic ischemic heart disease.
