A1 Refereed original research article in a scientific journal
Automatic statistical shape analysis of cerebral asymmetry in 3D T1-weighted magnetic resonance images at vertex-level – Application to neuroleptic-naive schizophrenia
Subtitle: Application to neuroleptic-naive schizophrenia
Authors: Pepe A, Zhao L, Koikkalainen J, Hietala J, Ruotsalainen U, Tohka J
Publisher: ELSEVIER SCIENCE INC
Publication year: 2013
Journal: Magnetic Resonance Imaging
Journal name in source: MAGNETIC RESONANCE IMAGING
Journal acronym: MAGN RESON IMAGING
Number in series: 5
Volume: 31
Issue: 5
First page : 676
Last page: 687
Number of pages: 12
ISSN: 0730-725X
DOI: https://doi.org/10.1016/j.mri.2012.10.021(external)
Abstract
The developed method was tested on scans obtained from a small sample of healthy volunteers and first-episode neuroleptic-naive schizophrenics. A significant main effect of the disease on the local interhemispheric asymmetry was observed, both in females and males, at the frontal and temporal lobes, the latter being often linked to the cognitive, auditory, and memory deficits in schizophrenia. The findings of this study, although need further testing in larger samples, partially replicate previous studies supporting the hypothesis of schizophrenia as a neurodevelopmental disorder. (C) 2013 Elsevier Inc. All rights reserved.
The developed method was tested on scans obtained from a small sample of healthy volunteers and first-episode neuroleptic-naive schizophrenics. A significant main effect of the disease on the local interhemispheric asymmetry was observed, both in females and males, at the frontal and temporal lobes, the latter being often linked to the cognitive, auditory, and memory deficits in schizophrenia. The findings of this study, although need further testing in larger samples, partially replicate previous studies supporting the hypothesis of schizophrenia as a neurodevelopmental disorder. (C) 2013 Elsevier Inc. All rights reserved.
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