A1 Refereed original research article in a scientific journal

Automatic statistical shape analysis of cerebral asymmetry in 3D T1-weighted magnetic resonance images at vertex-level – Application to neuroleptic-naive schizophrenia




SubtitleApplication to neuroleptic-naive schizophrenia

AuthorsPepe A, Zhao L, Koikkalainen J, Hietala J, Ruotsalainen U, Tohka J

PublisherELSEVIER SCIENCE INC

Publication year2013

JournalMagnetic Resonance Imaging

Journal name in sourceMAGNETIC RESONANCE IMAGING

Journal acronymMAGN RESON IMAGING

Number in series5

Volume31

Issue5

First page 676

Last page687

Number of pages12

ISSN0730-725X

DOIhttps://doi.org/10.1016/j.mri.2012.10.021(external)


Abstract
The developed method was tested on scans obtained from a small sample of healthy volunteers and first-episode neuroleptic-naive schizophrenics. A significant main effect of the disease on the local interhemispheric asymmetry was observed, both in females and males, at the frontal and temporal lobes, the latter being often linked to the cognitive, auditory, and memory deficits in schizophrenia. The findings of this study, although need further testing in larger samples, partially replicate previous studies supporting the hypothesis of schizophrenia as a neurodevelopmental disorder. (C) 2013 Elsevier Inc. All rights reserved.



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