A1 Refereed original research article in a scientific journal
Role of enterovirus infections in IgE sensitization
Authors: Seiskari T, Kondrashova A, Tauriainen S, Knip M, Viskari H, Haapala AM, Hyoty H
Publisher: WILEY-BLACKWELL
Publication year: 2012
Journal: Journal of Medical Virology
Journal name in source: JOURNAL OF MEDICAL VIROLOGY
Journal acronym: J MED VIROL
Number in series: 2
Volume: 84
Issue: 2
First page : 268
Last page: 271
Number of pages: 4
ISSN: 0146-6615
DOI: https://doi.org/10.1002/jmv.23186(external)
Abstract
Among other infectious agents, enteroviruses have been associated with protection against allergic diseases. The aim of the present study was to confirm these findings using a highly sensitive and specific neutralization antibody assay and to investigate whether the protective effect is related to certain enterovirus serotypes. Antibodies against 12 enterovirus serotypes were measured in 60 children who were positive for allergen-specific IgE and in 190 control children. Echoviruses seemed to be more protective than coxsackie-B-viruses and echovirus 11 had the strongest independent protective effect (P = 0.001; OR = 0.35, 95% CI: 0.180.67). The results support previous observations suggesting that infections by certain enterovirus types are associated with protection against IgE sensitization. J. Med. Virol. 84:268-271, 2012. (C) 2011 Wiley Periodicals, Inc.
Among other infectious agents, enteroviruses have been associated with protection against allergic diseases. The aim of the present study was to confirm these findings using a highly sensitive and specific neutralization antibody assay and to investigate whether the protective effect is related to certain enterovirus serotypes. Antibodies against 12 enterovirus serotypes were measured in 60 children who were positive for allergen-specific IgE and in 190 control children. Echoviruses seemed to be more protective than coxsackie-B-viruses and echovirus 11 had the strongest independent protective effect (P = 0.001; OR = 0.35, 95% CI: 0.180.67). The results support previous observations suggesting that infections by certain enterovirus types are associated with protection against IgE sensitization. J. Med. Virol. 84:268-271, 2012. (C) 2011 Wiley Periodicals, Inc.
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