The human leukocyte antigen genotype has a modest effect on the insulin gene polymorphism-associated susceptibility to type 1 diabetes in the Finnish population

: Laine AP, Hermann R, Knip M, Simell O, Akerblom HK, Ilonen J

Publisher: BLACKWELL MUNKSGAARD

: 2004

: Tissue Antigens

: TISSUE ANTIGENS

: 63

: 1

: 72

: 74

: 3

: 0001-2815

DOI: https://doi.org/10.1111/j.1399-0039.2004.00153.x

In addition to the known human leukocyte antigen (HLA)-associated risk, polymorphisms of insulin gene region show association with type 1 diabetes. We analyzed possible interactions between the HLA class II genotypes and -2221 MspI (insulin) INS gene polymorphism in Finnish population, using a series of 1331 diabetic children and 2222 healthy newborns. C/C genotype was increased among diabetic children compared to the controls (83.2 vs 70.1%). This genotype was slightly more common in diabetic children with low or moderate HLA-associated risk than in those with high risk, but INS gene effect was clear in all major HLA-risk genotypes and, thus, can be used as an additional risk prediction marker, irrespective of HLA genotypes.