Abstract Objectives. The aim of this study was to examine the effect of intermediate resin (IMR) of different monomer compositions and viscosities on the shear bond strength between polymer substrate and light-curing composite. Methods. The substrate used in the study was an autopolymerizing polymethyl methacrylate (PMMA) based polymer. The substrate was treated with the IMR for 3 min before application of light polymerizable particulate filler composite resin. The monomers of the IMR were either bisphenol-A-glycidyl dimethacrylate (BisGMA) and triethyleneglycol dimethacrylate (TEGDMA) or BisGMA and methyl methacrylate (MMA). The shear bond strength of the IMR treated substrate to the particulate filler composite was evaluated after storing the specimens dry and after thermocycling the specimens in water. Light microscope examination was accomplished to determine the swelled layer of the substrate. Results. Significant differences were found between the shear bond strength values of the IMRs (p  0.05). Conclusions. The results suggest that the monomer composition and ratio of the IMRs used in the study influence the shear bond strength of the polymer substrate to the new resin