The distribution of collagen types I, III, and IV in normal and malignant colorectal mucosa



: Hilska M, Collan Y, Peltonen J, Gullichsen R, Paajanen H, Laato M

Publisher: SCANDINAVIAN UNIVERSITY PRESS

: 1998

 European Journal of Surgery

: EUROPEAN JOURNAL OF SURGERY

: EUR J SURG

: 164

: 6

: 457

: 464

: 8

: 1102-4151


Conclusion: Both the epithelial basement membrane and the collagenous matrix immediately beneath it are degraded in malignant tissue. This may suggest the simultaneous activation of several degradative enzymes las type I and II collagens are at least in part degraded by different enzymes from type TV collagen) or alterations in the expression of collagen subtypes in normal compared with malignant tissue.


colon carcinoma, colonic mucosa, extracellular matrix, metastasis



Last updated on 13/10/2025 01:34:40 PM