The distribution of collagen types I, III, and IV in normal and malignant colorectal mucosa



: Hilska M, Collan Y, Peltonen J, Gullichsen R, Paajanen H, Laato M

Publisher: SCANDINAVIAN UNIVERSITY PRESS

: 1998

: European Journal of Surgery

: EUROPEAN JOURNAL OF SURGERY

: EUR J SURG

: 164

: 6

: 457

: 464

: 8

: 1102-4151


Conclusion: Both the epithelial basement membrane and the collagenous matrix immediately beneath it are degraded in malignant tissue. This may suggest the simultaneous activation of several degradative enzymes las type I and II collagens are at least in part degraded by different enzymes from type TV collagen) or alterations in the expression of collagen subtypes in normal compared with malignant tissue.



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