A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
Functional imaging studies of dopamine system and cognition in normal aging and Parkinson's disease
Tekijät: Kaasinen V, Rinne JO
Kustantaja: PERGAMON-ELSEVIER SCIENCE LTD
Julkaisuvuosi: 2002
Journal: Neuroscience and Biobehavioral Reviews
Tietokannassa oleva lehden nimi: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
Lehden akronyymi: NEUROSCI BIOBEHAV R
Artikkelin numero: PII S0149-7634(02)00065-9
Vuosikerta: 26
Numero: 7
Aloitussivu: 785
Lopetussivu: 793
Sivujen määrä: 9
ISSN: 0149-7634
DOI: https://doi.org/10.1016/S0149-7634(02)00065-9
Tiivistelmä
Modem functional imaging methods, such as positron emission tomography (PET) and single photon emission computed tomography (SPECT), provide non-invasive, quantitative tools for the direct measurement of neurotransmitter function in the living human brain. The dopamine system has been of key interest; first, because it has a prominant role in several cognitive and motor processes, and secondly because the tracers currently available for the dopamine system enable an effective investigation of various pre, post- and intra-synaptic processes. Recent functional imaging findings indicate that certain cognitive deficits associated with both normal aging and Parkinson's disease are modulated by changes in the brain dopamine system. This review covers the literature related to age-associated phenomena in the dopamine system studied with in vivo imaging. In particular, the focus is on describing and discussing the relationships between aging, cognition and the dopaminergic system in healthy subjects and in patients with Parkinson's disease. (C) 2002 Elsevier Science Ltd. All rights reserved.
Modem functional imaging methods, such as positron emission tomography (PET) and single photon emission computed tomography (SPECT), provide non-invasive, quantitative tools for the direct measurement of neurotransmitter function in the living human brain. The dopamine system has been of key interest; first, because it has a prominant role in several cognitive and motor processes, and secondly because the tracers currently available for the dopamine system enable an effective investigation of various pre, post- and intra-synaptic processes. Recent functional imaging findings indicate that certain cognitive deficits associated with both normal aging and Parkinson's disease are modulated by changes in the brain dopamine system. This review covers the literature related to age-associated phenomena in the dopamine system studied with in vivo imaging. In particular, the focus is on describing and discussing the relationships between aging, cognition and the dopaminergic system in healthy subjects and in patients with Parkinson's disease. (C) 2002 Elsevier Science Ltd. All rights reserved.
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