Deficiency in Melanocortin 1 Receptor Signaling Predisposes to Vascular Endothelial Dysfunction and Increased Arterial Stiffness in Mice and Humans



: Rinne P, Ahola-Olli A, Nuutinen S, Koskinen E, Kaipio K, Eerola K, Juonala M, Kahonen M, Lehtimaki T, Raitakari OT, Savontaus E

Publisher: LIPPINCOTT WILLIAMS & WILKINS

: 2015

: Arteriosclerosis, Thrombosis, and Vascular Biology

: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

: ARTERIOSCL THROM VAS

: 35

: 7

: 1678

: 1686

: 9

: 1079-5642

: 1524-4636

DOI: https://doi.org/10.1161/ATVBAHA.114.305064(external)


Conclusions The present study demonstrates that deficiency in MC1-R signaling is associated with increased arterial stiffness and impairment in endothelium-dependent vasodilatation, suggesting a physiological role for MC1-R in the regulation of arterial tone.




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