Deficiency in Melanocortin 1 Receptor Signaling Predisposes to Vascular Endothelial Dysfunction and Increased Arterial Stiffness in Mice and Humans - UTU Research Portal

A1 Refereed original research article in a scientific journal

Deficiency in Melanocortin 1 Receptor Signaling Predisposes to Vascular Endothelial Dysfunction and Increased Arterial Stiffness in Mice and Humans

Authors: Rinne P, Ahola-Olli A, Nuutinen S, Koskinen E, Kaipio K, Eerola K, Juonala M, Kahonen M, Lehtimaki T, Raitakari OT, Savontaus E

Publisher: LIPPINCOTT WILLIAMS & WILKINS

Publication year: 2015

Journal: Arteriosclerosis, Thrombosis, and Vascular Biology

Journal name in source: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Journal acronym: ARTERIOSCL THROM VAS

Volume: 35

Issue: 7

First page : 1678

Last page: 1686

Number of pages: 9

ISSN: 1079-5642

eISSN: 1524-4636

DOI: https://doi.org/10.1161/ATVBAHA.114.305064(external)

Abstract

Conclusions The present study demonstrates that deficiency in MC1-R signaling is associated with increased arterial stiffness and impairment in endothelium-dependent vasodilatation, suggesting a physiological role for MC1-R in the regulation of arterial tone.