Otto Kauko - UTU Research Portal - UTU Research Portal

Otto Kauko

- Research Director,
Turku Bioscience Centre (Independent units)

otkauko@utu.fi

Publications

2 of 3

Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A (2023)
- Nature Communications
Pavic Karolina, Gupta Nikhil, Omella Judit Domènech, Derua Rita, Aakula Anna, Huhtaniemi Riikka, Määttä Juha A, Höfflin Nico, Okkeri Juha, Wang Zhizhi, Kauko Otto, Varjus Roosa, Honkanen Henrik, Abankwa Daniel, Köhn Maja, Hytönen Vesa P, Xu Wenqing, Nilsson Jakob, Page Rebecca, Janssens Veerle, Leitner Alexander, Westermarck Jukka
(A1 Refereed original research article in a scientific journal)
Arginine Methyltransferase PRMT7 Deregulates Expression of RUNX1 Target Genes in T-Cell Acute Lymphoblastic Leukemia (2022)
- Cancers
Oksa Laura, Mäkinen Artturi, Nikkilä Atte, Hyvärinen Noora, Laukkanen Saara, Rokka Anne, Haapaniemi Pekka, Seki Masafumi, Takita Junko, Kauko Otto, Heinäniemi Merja, Lohi Olli
(A1 Refereed original research article in a scientific journal)
The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer (2021)
- Cell
Vervoort Stephin J, Welsh Sarah A, Devlin Jennifer R, Barbieri Elisa, Knight Deborah A, Offley Sarah, Bjelosevic Stefan, Costacurta Matteo, Todorovski Izabela, Kearney Conor J, Sandow Jarrod J, Fan Zheng, Blyth Benjamin, McLeod Victoria, Vissers Joseph HA, Pavic Karolina, Martin Ben P, Gregory Gareth, Demosthenous Elena, Zethoven Magnus, Kong Isabella Y, Hawkins Edwin D, Hogg Simon J, Kelly Madison J, Newbold Andrea, Simpson Kaylene J, Kauko Otto, Harvey Kieran F, Ohlmeyer Michael, Westermarck Jukka, Gray Nathanael, Gardini Alessandro, Johnstone Ricky W
(A1 Refereed original research article in a scientific journal)
Phosphoproteome and drug-response effects mediated by the three protein phosphatase 2A inhibitor proteins CIP2A, SET, and PME-1 (2020)
- Journal of Biological Chemistry
Kauko O, Imanishi SY, Kulesskiy E, Yetukuri L, Laajala TD, Sharma M, Pavic K, Aakula A, Rupp C, Jumppanen M, Haapaniemi P, Ruan L, Yadav B, Suni V, Varila T, Reimand J, Corthals GL, Aittokallio T, Wennerberg K, Westermarck J
(A1 Refereed original research article in a scientific journal)
Arpp19 Promotes Myc and Cip2a Expression and Associates with Patient Relapse in Acute Myeloid Leukemia (2019)
- Cancers
Mäkelä E, Löyttyniemi E, Salmenniemi U, Kauko O, Varila T, Kairisto V, Itälä-Remes M, Westermarck J
(A1 Refereed original research article in a scientific journal)
Non-genomic mechanisms of protein phosphatase 2A (PP2A) regulation in cancer (2018)
- International Journal of Biochemistry and Cell Biology
Otto Kauko, Jukka Westermarck
(A2 Refereed review article in a scientific journal )
Phosphonormalizer: an R package for normalization of MS-based label-free phosphoproteomics (2018)
- Bioinformatics
Sohrab Saraei, Tomi Suomi, Otto Kauko, Laura L. Elo
(A1 Refereed original research article in a scientific journal)
PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells (2018)
- Science Translational Medicine
Otto Kauko, Caitlin M. O’Connor, Evgeny Kulesskiy, Jaya Sangodkar, Anna Aakula, Sudeh Izadmehr, Laxman Yetukuri, Bhagwan Yadav, Artur Padzik, Teemu Daniel Laajala, Pekka Haapaniemi, Majid Momeny, Taru Varila, Michael Ohlmeyer, Tero Aittokallio, Krister Wennerberg, Goutham Narla, Jukka Westermarck
(A1 Refereed original research article in a scientific journal)
A Systems Biology Analysis of PP2A Functions in Cancer Cells (2017) Kauko Otto
(G5 Article dissertation )
Oncoprotein CIP2A is stabilized via interaction with tumor suppressor PP2A/B56 (2017)
- EMBO Reports
Jiao Wang, Juha Okkeri, Karolina Pavic, Zhizhi Wang, Otto Kauko, Tuuli Halonen, Grzegorz Sarek, Päivi M Ojala, Zihe Rao, Wenqing Xu, Jukka Westermarck
(A1 Refereed original research article in a scientific journal)