Jukka Hytönen
MD, PhD
jukhyt@utu.fi +358 29 450 4544 +358 50 509 5430 Kiinamyllynkatu 10 Turku |
Lyme borreliosis; Lyme disease
High school graduation 1987, Licentiate of Medicine, University of Turku, Finland 1996, Doctor of Medical Sciences (MD, PhD), University of
Turku 2003, Specialist in Clinical Microbiology 2007, Docent in Medical Microbiology, University of Turku 2011, Special Competence in Medical Education 2015.
Various research and teaching positions, University of Turku 1996–2012
Academy Research Fellow, University of Turku 2012-2017
Associate professor of bacteriology (tenure track), University of Turku 1.9.2017-31.8.2022
My project focuses on Lyme borreliosis (LB) and other tick borne
infections and addresses the following questions: Pathogenesis of LB and the
role of borrelia adhesins in the process. Molecular and cellular events in the
pathogenesis of Lyme neuroborreliosis. Development of novel diagnostic tools
for LB. Development of PET/CT imaging of LB. Antibiotic treatment of LB. Prevalence
of ticks and tick-borne pathogens in Finland. Epidemiology of LB and other
borrelioses in Finland.
Bacteriology; Infectious diseases laboratory diagnostics; Lyme borreliosis; Vector-borne infections; Tick-borne infections
- Vinkistä vihiä: Iäkkään miehen sitkeä käsi-ihottuma (2014)
- Duodecim
- Europium nanoparticle-based high performing immunoassay for the screening of treponemal antibodies (2013)
- PLoS ONE
- Puuttuva arpi (2013)
- Duodecim
- Serum matrix metalloproteinase-8 and -9 levels in disseminated lyme borreliosis with special reference to arthritis (2012)
- Bio
- Decorin Binding by DbpA and B of Borrelia garinii, Borrelia afzelii, and Borrelia burgdorferi Sensu Stricto (2011)
- Journal of Infectious Diseases
- Disordered Lymphoid Purine Metabolism Contributes to the Pathogenesis of Persistent Borrelia garinii Infection in Mice (2010)
- Journal of Immunology
- Persistence of borrelial DNA in the joints of Borrelia burgdorferi-infected mice after ceftriaxone treatment (2010)
- APMIS
- TLR2 Utilization of Borrelia does not induce p38- and IFN_2 autocrine loop-dependent expression of CD38, resulting in poor migration and weak IL-12 secretion of dendritic cells (2010)
- Journal of Immunology
- Leucine-rich Repeats of Bacterial Surface Proteins Serve as Common Pattern Recognition Motifs of Human Scavenger Receptor gp340 (2009)
- Journal of Biological Chemistry
- Bordetella pertussis isolates in Finland: Serotype and fimbrial expression (2008)
- BMC Microbiology
- Borrelia burgdorferi inhibits human neutrophil functions (2008)
- Microbes and Infection
- Borreliosis: recent research, diagnosis, and management (2008)
- Scandinavian Journal of Rheumatology
- Deficiency of the Rgg regulator promotes H2O2 resistance, AhpCF-mediated H2O2 decomposition, and virulence in Streptococcus pyogenes (2008)
- Journal of Bacteriology
- Anti-tumor necrosis factor-alpha treatment activates Borrelia burgdorferi spirochetes 4 weeks after ceftriaxone treatment in C3H/He mice (2007)
- Journal of Infectious Diseases
- Transcriptional response of human dendritic cells to Borrelia garinii - defective CD38 and CCR7 expression detected (2007)
- Journal of Leukocyte Biology
- Persistent joint swelling and borrelia-specific antibodies in Borrelia garinii-infected mice after eradication of vegetative spirochetes with antibiotic treatment (2006)
- Microbes and Infection
- Use of CFSE staining of borreliae in studies on the interaction between borreliae and human neutrophils (2006)
- BMC Microbiology
- Use of flow cytometry for the adhesion analysis of Streptococcus pyogenes mutant strains to epithelial cells: investigation of the possible role of surface pullulanase and cysteine protease, and the transcriptional regulator Rgg (2006)
- BMC Microbiology
- Fluid- or surface-phase human salivary scavenger protein gp340 exposes different bacterial recognition properties (2005)
- Infection and Immunity
- Streptococcus pyogenes glycoprotein-binding strepadhesin activity is mediated by a surface-associated carbohydrate-degrading enzyme, pullulanase (2003)
- Infection and Immunity