Henrik Paavilainen

- Docent,
Institute of Biomedicine (Faculty of Medicine)

hojpaa@utu.fi

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Decorin Expressed From Herpes Simplex Virus Vector Improves Oncolytic Efficacy in Lung Adenocarcinoma Cells (2025)
- Proteoglycan Research
Frejborg, Fanny; Palomäki, Jussi; Kalke, Kiira; Orpana, Julius; Koivisto, Oliver; Paavilainen, Henrik; Rosenholm, Jessica M.; Zhang, Hongbo; Hukkanen, Veijo; Järveläinen, Hannu
Attenuated Replication-Competent Herpes Simplex Virus Expressing an ECM-Modifying Transgene Hyaluronan Synthase 2 of Naked Mole Rat in Oncolytic Gene Therapy (2023)
- Microorganisms
Palomäki Jussi, Kalke Kiira, Orpana Julius, Lund Liisa, Frejborg Fanny, Paavilainen Henrik, Järveläinen Hannu, Hukkanen Veijo
Enzymatically synthesized 2 '-fluoro-modified Dicer-substrate siRNA swarms against herpes simplex virus demonstrate enhanced antiviral efficacy and low cytotoxicity (2020)
- Antiviral Research
Levanova Alesia A., Kalke Kiira M., Lund Liisa M., Sipari Nina, Sadeghi Mohammadreza, Nyman Marie C., Paavilainen Henrik, Hukkanen Veijo, Poranen Minna M.
Herpes Simplex Virus Type 1 Clinical Isolates Respond to UL29-Targeted siRNA Swarm Treatment Independent of Their Acyclovir Sensitivity (2020)
- Viruses
Kalke K, Lehtinen J, Gnjatovic J, Lund LM, Nyman MC, Paavilainen H, Orpana J, Lasanen T, Frejborg F, Levanova AA, Vuorinen T, Poranen MM, Hukkanen V
Comparison of Herpes Simplex Virus 1 Strains Circulating in Finland Demonstrates the Uncoupling of Whole-Genome Relatedness and Phenotypic Outcomes of Viral Infection (2019)
- Journal of Virology
Bowen CD, Paavilainen H, Renner DW, Palomäki J, Lehtinen J, Vuorinen T, Norberg P, Hukkanen V, Szpara ML
Herpes simplex and human papilloma virus coinfections in oral mucosa of men-A 6-year follow-up study (2018)
- Journal of Medical Virology
Mäki Johanna, Paavilainen Henrik, Kero Katja, Hukkanen Veijo, Syrjänen Stina
Novel activities of safe-in-human broad-spectrum antiviral agents (2018)
- Antiviral Research
Aleksandr Ianevski, Eva Zusinaite, Suvi Kuivanen, Mårten Strand, Hilde Lysvand, Mona Teppor, Laura Kakkola, Henrik Paavilainen, Mira Laajala, Hannimari Kallio-Kokko, Miia Valkonen, Anu Kantele, Kaidi Telling, Irja Lutsar, Pille Letjuka, Natalja Metelitsa, Valentyn Oksenych, Magnar Bjørås, Svein Arne Nordbø, Uga Dumpis, Astra Vitkauskiene, Christina Öhrmalm, Kåre Bondeson, Anders Bergqvist, Tero Aittokallio, Rebecca J. Cox, Magnus Evander, Veijo Hukkanen, Varpu Marjomaki, Ilkka Julkunen, Olli Vapalahti, Tanel Tenson, Andres Merits, Denis Kainov
Personalized Cancer Vaccine Platform for Clinically Relevant Oncolytic Enveloped Viruses (2018)
- Molecular Therapy
Erkko Ylösmäki, Cristina Malorzo, Cristian Capasso, Oona Honkasalo, Manlio Fusciello, Beatriz Martins, Leena Ylösmäki, Antti Louna, Sara Feola, Henrik Paavilainen, Karita Peltonen, Veijo Hukkanen, Tapani Viitala, Vincenzo Cerullo
Antiviral properties of chemical inhibitors of cellular anti-apoptotic Bcl-2 proteins (2017)
- Viruses
Daria Bulanova, Aleksandr Ianevski, Andrii Bugai, Yevhen Akimov, Suvi Kuivanen, Henrik Paavilainen, Laura Kakkola, Jatin Nandania, Laura Turunen, Tiina Ohman, Hanna Ala-Hongisto, Hanna M. Pesonen, Marika S. Kuisma, Anni Honkimaa, Emma L. Walton, Valentyn Oksenych, Martina B. Lorey, Dmitry Guschin, Jungmin Shim, Jinhee Kim, Thoa T. Than, So Young Chang, Veijo Hukkanen, Evgeny Kulesskiy, Varpu S. Marjomaki, Ilkka Julkunen, Tuula A. Nyman, Sampsa Matikainen, Jani S. Saarela, Famara Sane, Didier Hober, Gülsah Gabriel, Jef K. De Brabander, Miika Martikainen, Marc P. Windisch, Ji-Young Min, Roberto Bruzzone, Tero Aittokallio, Markus Vähä-Koskela, Olli Vapalahti, Arto Pulk, Vidya Velagapudi, Denis E. Kainov
Inhibition of herpes simplex virus infection with RNA interference (2017) Paavilainen Henrik
Regulation of kynurenine biosynthesis during influenza virus infection (2017)
- FEBS Journal
Gaelings L, Söderholm S, Bugai A, Fu Y, Nandania J, Schepens B, Lorey MB, Tynell J, Vande Ginste L, Le Goffic R, Miller MS, Kuisma M, Marjomäki V, De Brabander J, Matikainen S, Nyman T, Bamford D, Saelens X, Julkunen I, Paavilainen H, Hukkanen V, Velagapudi V, Kainov DE
Topical treatment of herpes simplex virus infection with enzymatically created siRNA swarm (2017)
- Antiviral Therapy
Henrik Paavilainen, Jenni Lehtinen, Alesia Romanovskaya, Michaela Nygårdas, Dennis H Bamford, Minna M Poranen, Veijo Hukkanen
Inhibition of clinical pathogenic herpes simplex virus 1 strains with enzymatically created siRNA pools (2016)
- Journal of Medical Virology
Paavilainen H, Lehtinen J, Romanovskaya A, Nygardas M, Bamford DH, Poranen MM, Hukkanen V
Interleukin-27 Inhibits Herpes Simplex Virus Type 1 Infection by Activating STAT1 and 3, Interleukin-6, and Chemokines IP-10 and MIG (2016)
- Journal of Interferon and Cytokine Research
Heikkila O, Nygardas M, Paavilainen H, Ryodi E, Hukkanen V
An investigation of herpes simplex virus type 1 latency in a novel mouse dorsal root ganglion model suggests a role for ICP34.5 in reactivation (2015)
- Journal of General Virology
Mattila RK, Harila K, Kangas SM, Paavilainen H, Heape AM, Mohr IJ, Hukkanen V
Carriage of herpes simplex virus and human papillomavirus in oral mucosa is rare in young women: A long-term prospective follow-up (2015)
- Journal of Clinical Virology
Mäki J, Paavilainen H, Grenman S, Syrjänen S, Hukkanen V
Innate responses to small interfering RNA pools inhibiting herpes simplex virus infection in astrocytoid and epithelial cells (2015)
- Innate Immunity
Henrik Paavilainen, Alesia Romanovskaya, Michaela Nygårdas, Dennis H Bamford, Minna M Poranen, Veijo Hukkanen
A Herpes Simplex Virus-Derived Replicative Vector Expressing LIF Limits Experimental Demyelinating Disease and Modulates Autoimmunity (2013)
- PLoS ONE
Nygardas M, Paavilainen H, Muther N, Nagel CH, Roytta M, Sodeik B, Hukkanen V
Anticancer compound ABT-263 accelerates apoptosis in virus-infected cells and imbalances cytokine production and lowers survival rates of infected mice (2013)
- Cell Death and Disease
Kakkola L, Denisova OV, Tynell J, Viiliainen J, Ysenbaert T, Matos RC, Nagaraj A, Ohman T, Kuivanen S, Paavilainen H, Feng L, Yadav B, Julkunen I, Vapalahti O, Hukkanen V, Stenman J, Aittokallio T, Verschuren EW, Ojala PM, Nyman T, Saelens X, Dzeyk K, Kainov DE
Enzymatically Produced Pools of Canonical and Dicer-Substrate siRNA Molecules Display Comparable Gene Silencing and Antiviral Activities against Herpes Simplex Virus (2012)
- PLoS ONE
Romanovskaya A, Paavilainen H, Nygardas M, Bamford DH, Hukkanen V, Poranen MM