Ph.D; Docent Zhi Chen - UTU Tutkimustietojärjestelmä

Zhi Chen
Ph.D; Docent

- Docent,
Institute of Biomedicine (Faculty of Medicine)

zchen@utu.fi

ORCID identifier: https://orcid.org/0000-0002-4658-7463

Areas of expertise

T cells; inflammation; autoimmune

Publications

CIP2A Constrains Th17 Differentiation by Modulating STAT3 Signaling (2020)
- iScience
Mohd Moin Khan, Ubaid Ullah, Meraj H. Khan, Lingjia Kong, Robert Moulder, Tommi Välikangas, Santosh Dilip Bhosale, Elina Komsi, Omid Rasool, Zhi Chen, Laura L. Elo, Jukka Westermarck, Riitta Lahesmaa
(A1 Refereed original research article in a scientific journal)
NF-kappa B Signaling and IL-4 Signaling Regulate SATB1 Expression via Alternative Promoter Usage During Th2 Differentiation (2019)
- Frontiers in immunology
Satyajeet P. Khare, Ankitha Shetty, Rahul Biradar, Indumathi Patta, Zhi Jane Chen, Ameya V. Sathe, Puli Chandramouli Reddy, Riitta Lahesmaa, Sanjeev Galande
(A1 Refereed original research article in a scientific journal)
Estrogen receptor alpha contributes to T cell-mediated autoimmune inflammation by promoting T cell activation and proliferation (2018)
- Science Signaling
Mohammad I, Starskaia I, Nagy T, Guo JT, Yatkin E, Väänänen K, Watford WT, Chen Z
(A1 Refereed original research article in a scientific journal)
Quantitative proteomic characterization and comparison of T helper 17 and induced regulatory T cells (2018)
- PLoS Biology
Imran Mohammad, Kari Nousiainen, Santosh D. Bhosale, Inna Starskaia, Robert Moulder, Anne Rokka, Fang Cheng, Ponnuswamy Mohanasundaram, John E. Eriksson, David R. Goodlett, Harri Lähdesmäki, Zhi Chen
(A1 Refereed original research article in a scientific journal)
AMIGO2 modulates T cell functions and its deficiency in mice ameliorates experimental autoimmune encephalomyelitis (2017)
- Brain, Behavior, and Immunity
Zhilin Li, Mohd Moin Khan, Juha Kuja-Panula, Hongyun Wang, Yu Chen, Deyin Guo, Zhi Jane Chen, Riitta Lahesmaa, Heikki Rauvala, Li Tian,
(A1 Refereed original research article in a scientific journal)
Genome-wide Analysis of STAT3-Mediated Transcription during Early Human Th17 Cell Differentiation (2017)
- Cell Reports
Tripathi Subhash K, Chen Zhi, Larjo Antti, Kanduri Kartiek, Nousiainen Kari, Aijo Tarmo, Ricano-Ponce Isis, Hrdlickova Barbara, Tuomela Soile, Laajala Essi, Salo Verna, Kumar Vinod, Wijmenga Cisca, Lahdesmaki Harri, Lahesmaa Riitta
(A1 Refereed original research article in a scientific journal)
CIP2A Promotes T-Cell Activation and Immune Response to Listeria monocytogenes Infection (2016)
- PLoS ONE
Côme C, Cvrljevic A, Khan MM, Treise I, Adler T, Aguilar-Pimentel JA, Au-Yeung B, Sittig E, Laajala TD, Chen Y, Oeder S, Calzada-Wack J, Horsch M, Aittokallio T, Busch DH, Ollert MW, Neff F, Beckers J, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Chen Z, Lahesmaa R, Westermarck J
(A1 Refereed original research article in a scientific journal)
Comparative analysis of human and mouse transcriptomes of Th17 cell priming (2016)
- Oncotarget
Soile Tuomela, Sini Rautio, Helena Ahlfors, Viveka Öling, Verna Salo,
Ubaid Ullah, Zhi Chen, Saara Hämälistö, Subhash K. Tripathi, Tarmo Äijö,
Omid Rasool, Hayssam Soueidan, Lodewyk Wessels, Brigitta Stockinger,
Harri Lähdesmäki, Riitta Lahesmaa
(A1 Refereed original research article in a scientific journal)
Analyzing Th17 cell differentiation dynamics using a novel integrative modeling framework for time-course RNA sequencing data (2015)
- BMC Systems Biology
Intosalmi J, Ahlfors H, Rautio S, Mannerstom H, Chen ZJ, Lahesmaa R, Stockinger B, Lahdesmaki H
(A1 Refereed original research article in a scientific journal)
Methods for time series analysis of RNA-seq data with application to human Th17 cell differentiation (2014)
- Bioinformatics
Äijö Tarmo, Butty Vincent, Chen Zhi, Salo Verna, Tripathi Subhash, Burge Christopher B, Lahesmaa Riitta, Lähdesmäki Harri
(A1 Refereed original research article in a scientific journal)
Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub (2014)
- Nature Immunology
Roncagalli R, Hauri S, Fiore F, Liang Y, Chen Z, Sansoni A, Kanduri K, Joly R, Malzac A, Lähdesmäki H, Lahesmaa R, Yamasaki S, Saito T, Malissen M, Aebersold R, Gstaiger M, Malissen B
(A1 Refereed original research article in a scientific journal)
Reactive Oxygen Species Deficiency Induces Autoimmunity with Type 1 Interferon Signature (2014)
- Antioxidants and Redox Signaling
Kelkka Tiina, Kienhöfer Deborah, Hoffmann Markus, Linja Marjo, Wing Kajsa, Sareila Outi, Hultqvist Malin, Laajala Essi, Chen Zhi, Vasconcelos Julia, Neves Esmeralda, Guedes Margarida, Marques Laura, Krönke Gerhard, Helminen Merja, Kainulainen Leena, Olofsson Peter, JalkanenSirpa, Lahesmaa Riitta, Souto-Carneiro M. Margarida, Holmdahl Rikard
(A1 Refereed original research article in a scientific journal)
From a gene-centric to whole-proteome view of differentiation of T helper cell subsets (2013)
- Briefings in Functional Genomics
Lonnberg T, Chen Z, Lahesmaa R
(A1 Refereed original research article in a scientific journal)
Identification of early gene expression changes during human Th17 cell differentiation (2012)
- Blood
Tuomela Soile, Salo Verna, Tripathi Subhash K, Chen Zhi, Laurila Kirsti, Gupta Bhawna, Äijö Tarmo, Oikari Lotta, Stockinger Brigitta, Lähdesmäki Harri, Lahesmaa Riitta
(A1 Refereed original research article in a scientific journal)
Early target genes of IL-12 and STAT4 signaling in th cells. (2004)
- Journal of Immunology
Lund RJ, Chen Z, Scheinin J, Lahesmaa R.
(A1 Refereed original research article in a scientific journal)
Identification of novel IL-4/Stat6-regulated genes in T lymphocytes. (2003)
- Journal of Immunology
Chen Z, Lund R, Aittokallio T, Kosonen M, Nevalainen O, Lahesmaa R.
(A1 Refereed original research article in a scientific journal)