Hannu Järveläinen
Professor
hanjar@utu.fi +358 29 450 4629 +358 46 922 9617 Kiinamyllynkatu 10 Turku |
extracellular matrix; proteoglycans; decorin; hyaluronan, vascular biology, cancer biology, diabetes, biobank
The extracellular matrix (ECM) consists of numerous macromolecules that
can be classified into collagens, elastin, and microfibrillar proteins,
proteoglycans including hyaluronan, and noncollagenous glycoproteins.
Together they form a complex, three-dimensional network among the cells
of different tissues in an organ-specific manner. In addition to being
necessary structural components, ECM macromolecules exhibit important
functional roles in the control of key cellular events such as adhesion,
migration, proliferation, differentiation, and survival. Any structural
inherited or acquired defect and/or metabolic disturbance in the ECM
macromolecules may cause cellular and tissue alterations that can lead
to the development or progression of disease. Consequently, ECM
macromolecules are important targets for pharmacotherapy. Our interest
has been for a long time to study the role of matrix proteoglycans (PGs)
including hyaluronan in vascular biology. We have particularly focused
on the involvement of a small PG decorin with atherogenesis and
angiogenesis. Lately we have also examined the role of decorin in
tumourigenesis. Our ultimate goal is to develop decorin-based therapies
to prevent luminal narrowing of arteries, to inhibit pathological
angiogenesis and to restrict tumour growth and metastasis.
- Diabeteksen hoidon toteutuminen ja kustannukset perusterveydenhuollossa: Esimerkkinä Paimion–Sauvon kansanterveyskuntayhtymä (2020)
- Lääkärilehti
- Extracellular matrix-cell interactions: Focus on therapeutic applications (2020)
- Cellular Signalling
- Haavan paraneminen - diabetes sekä muut esteet ja hidasteet (2020)
- Duodecim
- Metformin decreases hyaluronan synthesis by vascular smooth muscle cells (2020)
- Journal of Investigative Medicine
- Ajaessa ilmenevä hypoglykemia (2019) Diabetes Hannu Järveläinen
- Charcot'n jalka (2019) Diabetes Hannu Järveläinen, Jorma Lahtela
- Decorin Expression and Oncosuppression in Human Embryonic Carcinomas (2019)
- Archives of Clinical and Medical Case Reports
- Decorin Expression in Human Vulva Carcinoma: Oncosuppressive Effect of Decorin cDNA Transduction on Carcinoma Cells (2019)
- Journal of Histochemistry and Cytochemistry
- Decorin-mediated oncosuppression – a potential future adjuvant therapy for human epithelial cancers (2019)
- British Journal of Pharmacology
- Diabeettinen polyneuropatia alaraajoissa (2019) Diabetes Hannu Järveläinen, Jorma Lahtela, Tapani Ebeling
- Diabeettisten jalkaongelmien syntyyn vaikuttavat tekijät, yleisyys ja kustannukset (2019) Diabetes Hannu Järveläinen, Tapani Ebeling
- Diabetekseen liittyvät alaraajojen verisuonisairaudet (2019) Diabetes Pirkka Vikatmaa, Hannu Järveläinen
- Diabetekseen liittyvät jalkainfektiot ja niiden konservatiivinen hoito (2019) Diabetes Hannu Järveläinen, Jorma Lahtela
- Diabetesta sairastavan ajoturvallisuus (2019) Diabetes Hannu Järveläinen
- Diabetesta sairastavan jalkojenhoidon järjestäminen (2019) Diabetes Anna-Leena Tapio, Jaana Huhtanen, Hannu Järveläinen
- Diabetesta sairastavan jalkojen neurologinen perustutkimus (2019) Diabetes Hannu Järveläinen, Tapani Ebeling
- Diabetesta sairastavan jalkojen perustutkimus (2019) Diabetes Hannu Järveläinen, Tapani Ebeling
- Diabetesta sairastavan riskijalan tunnistaminen (2019) Diabetes Hannu Järveläinen, Tapani Ebeling, Anna-Leena Tapio, Jaana Huhtanen
- Diabetesta sairastavan terveysvaatimukset ajokortin myöntämiselle (2019) Diabetes Hannu Järveläinen
- Diabetesta sairastavan terveysvaatimukset rautatieliikenteessä, merenkulussa ja ilmailussa (2019) Diabetes Hannu Järveläinen