Kaisa Ivaska-Papaioannou
PhD, Associate professor (docent)
kaisa.ivaska@utu.fi +358 29 450 4622 +358 50 407 6533 Kiinamyllynkatu 10 Turku Medisiina C Office: C440 ORCID identifier: https://orcid.org/0000-0001-7482-7623 |
bone; bone cell biology; bone metabolism; bone turnover markers; bone marrow adiposity; osteoporosis; diabetes; biomedicine; cell biology
Senior Lecturer in Cell Biology and Metabolism
Docent in Cell Biology 2012
Bone and energy metabolism
Our reserach group is interested in the crosstalk between bone cells and energy metabolism.
Bone is not only a structural organ but interacts with other cell types in the bone marrow microenvironment and iwith extra-skeletal cells via secreted hormone-like factors. Our current research focuses on role of these bone-derived hormones, or osteokines, in local and whole body energy metabolism, and the interactions between bone-forming osteoblasts and bone marrow adipocytes in the bone microenvironment. We are also interested in the effects of type 2 diabetes on bone cells and bone metabolism. Our long term goal is to understand how changes in energy metabolism affect bone cells, bone-derived hormones, bone turnover and bone microenvironment. We use cell culture and cell-based methods, in vivo models and patient samples obtained from clinical collaborators.
Group members: Milja Arponen (doctoral researcher), Niki Jalava (doctoral researcher), Nicko Widjaja (doctoral researcher), Ronja Ojala (doctoral researcher, Turku PET Centre), Iida Karhu (undergraduate student)
Funding: Academy of Finland, Laboratoriolääketieteen edistämissäätiö, Turku University Foundation, Diabetes Wellness Finland
- Cell biology and histology for students in Medicine (first year) and Biomedicine (Bachelor’s Degree Programme).
- Textbooks we use: Alberts et al. Essential Cell Biology, Alberts et al. Molecular BIology of the Cell, Young et al. Wheater's Functional Histology.
- Laboratory course "Cell and Molecular Biology (laboratory work)" for students in Biomedicine
- Laboratory course "Methods in Cell Biology" and for medical students selected for Molecular Medicine Research Track (2-yr programme).
- Mentoring students in biomedicine (3-yr Bachelor’s Degree Programme).
- Participating actively in the planning of the curriculum (in particular, first year BSc studies).
- Bone marrow metabolism is affected by body weight and response to exercise training varies according to anatomical location (2023)
- Diabetes, Obesity and Metabolism
(Refereed journal article or data article (A1)) - Perilipin-1 immunostaining improves semi-automated digital quantitation of bone marrow adipocytes in histological bone sections (2023)
- Adipocyte
(Refereed journal article or data article (A1)) - The evolution of the adolescent growth spurt: Urinary biomarkers of bone turnover in wild chimpanzees (Pan troglodytes) (2023)
- Journal of Human Evolution
(Refereed journal article or data article (A1)) - Age-Progressive and Gender-Dependent Bone Phenotype in Mice Lacking Both Ebf1 and Ebf2 in Prrx1-Expressing Mesenchymal Cells (2022)
- Calcified Tissue International
(Refereed journal article or data article (A1)) - Ben som endokrint organ: skelettets samverkan med övriga vävnader kan ge benmarkörer nya innebörder (2022)
- Klinisk Biokemi i Norden
(Article in trade journal or blog post (D1)) - Bone Turnover Marker Profiling and Fracture Risk in Older Women: Fracture Risk from Age 75 to 90 (2022)
- Calcified Tissue International
(Refereed journal article or data article (A1)) - Glucose transporters GLUT1, GLUT3, and GLUT4 have different effects on osteoblast proliferation and metabolism (2022)
- Frontiers in Physiology
(Refereed journal article or data article (A1)) - Guidelines for Biobanking of Bone Marrow Adipose Tissue and Related Cell Types: Report of the Biobanking Working Group of the International Bone Marrow Adiposity Society (2021)
- Frontiers in Endocrinology
(Refereed review article in scientific journal (A2)) - Luu endokriinisenä elimenä: luuston vuorovaikutukset muiden kudosten kanssa voivat antaa uusia merkityksiä luumerkkiaineille (2021)
- Kliin lab
(Article in trade journal or blog post (D1)) - Serum and Urinary Osteocalcin in Healthy 7- to 19-Year-Old Finnish Children and Adolescents (2021)
- Frontiers in Pediatrics
(Refereed journal article or data article (A1)) - Bone Marrow Metabolism Is Impaired in Insulin Resistance and Improves After Exercise Training (2020)
- Journal of Clinical Endocrinology and Metabolism
(Refereed journal article or data article (A1)) - Effects of FGFR inhibitors TKI258, BGJ398 and AZD4547 on breast cancer cells in 2D, 3D and tissue explant cultures (2020)
- Cellular Oncology
(Refereed journal article or data article (A1)) - Human Bone Marrow Adipose Tissue is a Metabolically Active and Insulin-Sensitive Distinct Fat Depot (2020)
- Journal of Clinical Endocrinology and Metabolism
(Refereed journal article or data article (A1)) - Recombinant Antibodies with Unique Specificities Allow for Sensitive and Specific Detection of Uncarboxylated Osteocalcin in Human Circulation (2020)
- Calcified Tissue International
(Refereed journal article or data article (A1)) - Dovitinib dilactic acid reduces tumor growth and tumor-induced bone changes in an experimental breast cancer bone growth model (2019)
- Journal of Bone Oncology
(Refereed journal article or data article (A1)) - Low free 25-hydroxyvitamin D and high vitamin D binding protein and parathyroid hormone in obese Caucasians. A complex association with bone? (2018)
- PLoS ONE
(Refereed journal article or data article (A1)) - Role of fibroblast growth factor receptors (FGFR) and FGFR like-1 (FGFRL1) in mesenchymal stromal cell differentiation to osteoblasts and adipocytes (2018)
- Molecular and Cellular Endocrinology
(Refereed journal article or data article (A1)) - Testicular Function and Bone in Young Men with Severe Childhood-Onset Obesity (2018)
- Hormone Research in Paediatrics
(Refereed journal article or data article (A1)) - Changes in bone metabolism after bariatric surgery by gastric bypass or sleeve gastrectomy (2017)
- BONE
(Refereed journal article or data article (A1)) - Bone mineral density is increased after a 16-week resistance training intervention in elderly women with decreased muscle strength (2016)
- European Journal of Endocrinology
(Refereed journal article or data article (A1))