Tiina Laitala
tilale@utu.fi +358 29 450 4619 +358 50 477 9873 Kiinamyllynkatu 10 Turku ORCID identifier: https://orcid.org/0000-0002-6249-5710(external) |
Areas of expertise
mTBI; microRNA; imaging; concussion; neuroanatomy; visuomotor research; tissue trauma healing; skeletal biology; sports trauma
mTBI; microRNA; imaging; concussion; neuroanatomy; visuomotor research; tissue trauma healing; skeletal biology; sports trauma
Research
Our research focuses on the mechanisms involved in short regulatory RNA physiology. These molecules (siRNAs, shRNAs, microRNAs) modulate gene expression, thus affecting not only differentiation and developmental maturation of cells and organ systems, but also tissue healing after trauma.
Teaching
- Neuroanatomy
- Human gross anatomy
- Histology
- Cell biology
- Sports trauma
Publications
- Solid-Supported NOTA and DOTA Chelators Useful for the Synthesis of 3 '-Radiometalated Oligonucleotides (2012)
- Bioconjugate Chemistry
(A1 Refereed original research article in a scientific journal) - Micro-RNAs regulate the differentiation of human bone marrow-derived MSCs (2011)
- BONE
(A1 Refereed original research article in a scientific journal) - Receptor tyrosine kinase inhibition causes simultaneous bone loss and excess bone formation within growing bone in rats. (2011)
- Toxicology and Applied Pharmacology
(A1 Refereed original research article in a scientific journal) - Snorc is a novel cartilage specific small membrane proteoglycan expressed in differentiating and articular chondrocytes (2011)
- Osteoarthritis and Cartilage
(A1 Refereed original research article in a scientific journal) - Tyrosine kinase inhibition by imatinib mesylate interferes with bone growth and remodellation in rats (2011)
- BONE
(Other publication) - Degradation of hydroxyapatite in vivo and in vitro requires osteoclastic sodium-bicarbonate co-transporter NBCn1 (2010)
- Matrix Biology
(A1 Refereed original research article in a scientific journal) - Impact of stromal cell composition on BMP-induced chondrogenic differentiation of mouse bone marrow derived mesenchymal cells (2008)
- Experimental Cell Research
(A1 Refereed original research article in a scientific journal) - MicroRNAs regulate osteogenesis and chondrogenesis of mouse bone marrow stromal cells (2008)
- Cellular Oncology [continued by Analytical Cellular Pathology]
(A1 Refereed original research article in a scientific journal) - MicroRNAs Regulate Osteogenesis and Chondrogenesis of Mouse Bone Marrow Stromal Cells (2008)
- Gene Regulation and Systems Biology
(A1 Refereed original research article in a scientific journal) - Osteoclast lineage and function (2008)
- Archives of Biochemistry and Biophysics
(A2 Refereed review article in a scientific journal ) - Recombinant VSV G proteins reveal a novel raft-dependent endocytic pathway in resorbing osteoclasts (2008)
- Experimental Cell Research
(A1 Refereed original research article in a scientific journal) - Electroneutral sodium/bicarbonate cotransporter NBCn1 is expressed in rat osteoclast ruffled border membrane (2007)
- Journal of Bone and Mineral Research
(A1 Refereed original research article in a scientific journal) - In silico promoter analysis of vacuolar proton pump subunits (2007)
- Calcified Tissue International
(A1 Refereed original research article in a scientific journal) - Membrane-bound carbonic anhydrases in osteoclasts (2007) Riihonen R, Supuran CT, Parkkila S, Pastorekova S, Vaananen HK, Laitala-Leinonen T
(A1 Refereed original research article in a scientific journal) - RNA interference tolerates 2 '-fluoro modifications at the Argonaute2 cleavage site (2007)
- Chemistry and Biodiversity
(A1 Refereed original research article in a scientific journal) - Sequence and TLR9 independent increase of TRACP expression by antisense DNA and siRNA molecules (2007)
- Biochemical and Biophysical Research Communications
(A1 Refereed original research article in a scientific journal) - Cystatin B as an intracellular modulator of bone resorption (2006)
- Matrix Biology
(A1 Refereed original research article in a scientific journal) - Toll-like receptor 9 knockout mice exhibit age and gender specific differences in regulation of bone modeling. (2006)
- Journal of Bone and Mineral Research
(A1 Refereed original research article in a scientific journal) - Inhibition of the osteoclast V-ATPase by small interfering RNAs (2005)
- FEBS Letters
(A1 Refereed original research article in a scientific journal) - Osteoclast function relies on raft-dependent vesicle trafficking between the ruffled border and the functional secretory domain (2005) Mulari MTK, Nars M, Kaisto T, Metsikko K, Laitala-Leinonen T, Vaananen K
(A1 Refereed original research article in a scientific journal)