Tiina Laitala - UTU Research Portal

Tiina Laitala

- Docent,
- University Lecturer
Institute of Biomedicine (Faculty of Medicine)

tilale@utu.fi

+358 29 450 4619

+358 50 477 9873

Kiinamyllynkatu 10

Turku

ORCID identifier: https://orcid.org/0000-0002-6249-5710

Areas of expertise

mTBI; microRNA; imaging; concussion; neuroanatomy; visuomotor research; tissue trauma healing; skeletal biology; sports trauma

Research

Our research focuses on the mechanisms involved in short regulatory RNA physiology. These molecules (siRNAs, shRNAs, microRNAs) modulate gene expression, thus affecting not only differentiation and developmental maturation of cells and organ systems, but also tissue healing after trauma.

Teaching

Neuroanatomy
Human gross anatomy
Histology
Cell biology
Sports trauma

Publications

2 of 3

Solid-Supported NOTA and DOTA Chelators Useful for the Synthesis of 3 '-Radiometalated Oligonucleotides (2012)
- Bioconjugate ChemistryGene Regulation and Systems Biology
Kiviniemi A, Makela J, Makila J, Saanijoki T, Liljenback H, Poijarvi-Virta P, Lonnberg H, Laitala-Leinonen T, Roivainen A, Virta P
(A1 Refereed original research article in a scientific journal)
Micro-RNAs regulate the differentiation of human bone marrow-derived MSCs (2011)
- BONE
Laine S, Virtanen S, Alm J, Aro H, Laitala-Leinonen T
(A1 Refereed original research article in a scientific journal)
Receptor tyrosine kinase inhibition causes simultaneous bone loss and excess bone formation within growing bone in rats. (2011)
- Toxicology and Applied PharmacologyArchives of Biochemistry and Biophysics
Nurmio M, Joki H, Kallio J, Määttä JA, Väänänen HK, Toppari J, Jahnukainen K, Laitala-Leinonen T
(A1 Refereed original research article in a scientific journal)
Snorc is a novel cartilage specific small membrane proteoglycan expressed in differentiating and articular chondrocytes (2011)
- Osteoarthritis and Cartilage
Heinonen J, Taipaleenmaki H, Roering P, Takatalo M, Harkness L, Sandholm J, Uusitalo-Jarvinen H, Kassem M, Kiviranta I, Laitala-Leinonen T, Saamanen AM
(A1 Refereed original research article in a scientific journal)
Tyrosine kinase inhibition by imatinib mesylate interferes with bone growth and remodellation in ratsRecombinant VSV G proteins reveal a novel raft-dependent endocytic pathway in resorbing osteoclasts (2011)
- BONEExperimental Cell Research
Joki H, Nurmio M, Kallio J, Maatta J, Vaananen K, Toppari J, Jahnukainen K, Laitala-Leinonen T
(Other publication)
Degradation of hydroxyapatite in vivo and in vitro requires osteoclastic sodium-bicarbonate co-transporter NBCn1 (2010)
- Matrix Biology
Riihonen R, NIELSEN S, VAANANEN HK, Laitala-Leinonen T, KWON TH
(A1 Refereed original research article in a scientific journal)
Impact of stromal cell composition on BMP-induced chondrogenic differentiation of mouse bone marrow derived mesenchymal cells (2008)
- Experimental Cell Research
Taipaleenmaki H, Suomi S, Hentunen T, Laitala-Leinonen T, Saamanen AM
(A1 Refereed original research article in a scientific journal)
MicroRNAs regulate osteogenesis and chondrogenesis of mouse bone marrow stromal cells (2008)
- Cellular Oncology [continued by Analytical Cellular Pathology]
Suomi S, Taipaleenmaki H, Seppaenen A, Vaananen K, Hentimen T, Saamanen AM, Laitala-Leinonen T
(A1 Refereed original research article in a scientific journal)
MicroRNAs Regulate Osteogenesis and Chondrogenesis of Mouse Bone Marrow Stromal Cells (2008)
Suomi S, Taipaleenmaki H, Seppanen A, Ripatti T, Vaananen K, Hentunen T, Saamanen AM, Laitala-Leinonen T
(A1 Refereed original research article in a scientific journal)
Osteoclast lineage and function (2008)
Vaananen HK, Laitala-Leinonen T
(A2 Refereed review article in a scientific journal )
(2008)
Mulari MTK, Nars M, Laitala-Leinonen T, Kaisto T, Metsikko K, Sun Y, Vaananen HK
(A1 Refereed original research article in a scientific journal)
Electroneutral sodium/bicarbonate cotransporter NBCn1 is expressed in rat osteoclast ruffled border membrane (2007)
- Journal of Bone and Mineral Research
Riihonen R, Song I, Nielsen S, Laitala-Leinonen T, Kwon T
(A1 Refereed original research article in a scientific journal)
In silico promoter analysis of vacuolar proton pump subunits (2007)
- Calcified Tissue International
Seppanen A, Vuorikoski H, Nyman J, Laitala-Leinonen T, Vaananen HK
(A1 Refereed original research article in a scientific journal)
Membrane-bound carbonic anhydrases in osteoclasts (2007) Riihonen R, Supuran CT, Parkkila S, Pastorekova S, Vaananen HK, Laitala-Leinonen T
(A1 Refereed original research article in a scientific journal)
RNA interference tolerates 2 '-fluoro modifications at the Argonaute2 cleavage site (2007)
- Chemistry and Biodiversity
Muhonen P, Tennila T, Azhayeva E, Parthasarathy RN, Janckila AJ, Vaananen HK, Azhayev A, Laitala-Leinonen T
(A1 Refereed original research article in a scientific journal)
Sequence and TLR9 independent increase of TRACP expression by antisense DNA and siRNA molecules (2007)
- Biochemical and Biophysical Research Communications
Muhonen P, Avnet S, Parthasarathy RN, Janckila AJ, Halleen JM, Laitala-Leinonen T, Vaananen HK
(A1 Refereed original research article in a scientific journal)
Cystatin B as an intracellular modulator of bone resorption (2006)
- Matrix Biology
Laitala-Leinonen T, Rinne R, Saukko P, Vaananen HK, Rinne A
(A1 Refereed original research article in a scientific journal)
Toll-like receptor 9 knockout mice exhibit age and gender specific differences in regulation of bone modeling. (2006)
- Journal of Bone and Mineral Research
Peng Z, Hentunen TA, Laitala-Leinonen T, Vaananen K, Selander KS
(A1 Refereed original research article in a scientific journal)
Inhibition of the osteoclast V-ATPase by small interfering RNAs (2005)
- FEBS Letters
Hu YW, Nyman J, Muhonen P, Vaananen HK, Laitala-Leinonen T
(A1 Refereed original research article in a scientific journal)
Osteoclast function relies on raft-dependent vesicle trafficking between the ruffled border and the functional secretory domain (2005) Mulari MTK, Nars M, Kaisto T, Metsikko K, Laitala-Leinonen T, Vaananen K
(A1 Refereed original research article in a scientific journal)