Klaus Elenius
MD, PhD, professor
ACTIONABLE RECEPTOR TYROSINE KINASE SIGNALING
Our goal is to understand how receptor tyrosine kinases (RTK) regulate the pathogenesis of human diseases, such as cancer. This information is needed for the development of molecularly targeted therapies. To recognize aberrations of RTK signaling in diseased tissue our laboratory also works on the molecular mechanism by which RTKs control normal processes, such as embryonic development. The work mainly focuses on the ErbB family of RTKs. Our laboratory has contributed to the field by e.g. by characterizing novel RTK signaling mechanisms, by identifying novel ErbB4 isoforms, and by determining the role of ErbBs and their ligands in angiogenesis.
Current topics
- Screens for predictive RTK mutations
- Novel RTK signaling mechanisms
- Development of preclinical models for development novel RTK inhibitors
- Sequencing of RTK inhibitor drug administration with cytotoxic agents
- In vitro “basket trials” with ErbB inhibitor drugs
- RTK signaling in angiogenesis and cardiovascular diseases
- RTKs in pediatric malignancies
- Biological role of novel ErbB4 isoforms in diseases and development
Elenius Lab members
- Anne Jokilammi, PhD
- Elli Narvi, PhD
- Deepankar Chakroborty, MSc
- Juho Heliste, MD
- Marika Koivu, MSc
- Johannes Merilahti, MSc
- Veera Ojala, MSc
- Janne Nordberg, MD
- Fred Saarinen, MSc
- Katri Vaparanta, MSc
- Kaisa Aalto, BM
- Maria Helkkula, BM
- Matias Mäenpää, BM
- Peppi Kirjalainen, BM
- Jori Torkkila, BM
- Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation (2020)
- Journal of Visualized Experiments
Mahlet Z. Tamirat, Kari J. Kurppa, Klaus Elenius, Mark S. Johnson
- Erbb4 regulates the oocyte microenvironment during folliculogenesis (2020) Veikkolainen V, Ali N, Doroszko M, Kiviniemi A, Miinalainen I, Ohlsson C, Poutanen M, Rahman N, Elenius K, Vainio SJ, Naillat F
- Genetic analysis of obstructive sleep apnoea discovers a strong association with cardiometabolic health (2020)
- European Respiratory Journal
Strausz S, Ruotsalainen S, Ollila HM, Karjalainen J, Kiiskinen T, Reeve M, Kurki M, Mars N, Havulinna AS, Luonsi E, Mansour Aly D, Ahlqvist E, Teder-Laving M, Palta P, Groop L, Mäkitie A, Mägi R, Bachour A, Salomaa V, Palotie A, Tuomi T, Ripatti S, Palotie T, Ripatti S; FinnGen research group
- Genetic and functional implications of an exonic TRIM55 variant in heart failure (2020)
- Journal of Molecular and Cellular Cardiology
Juho Heliste, Himanshu Chheda, Ilkka Paatero, Tiina A. Salminen, Yevhen Akimoc, Jere Paavola, Klaus Elenius, Tero Aittokallio
- Genomic prediction of alcohol-related morbidity and mortality (2020) Kiiskinen T, Mars NJ, Palviainen T, Koskela J, Ramo JT, Ripatti P, Ruotsalainen S, Palotie A, Madden PAF, Rose RJ, Kaprio J, Salomaa V, Makela P, Havulinna AS, Ripatti S
- Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells (2020) Erik L. Bao, Satish K. Nandakumar, Xiaotian Liao, Alexander G. Bick, Juha Karjalainen, Marcin Tabaka, Olga I. Gan, Aki S. Havulinna, Tuomo T. J. Kiiskinen, Caleb A. Lareau, Aitzkoa L. de Lapuente Portilla, Bo Li, Connor Emdin, Veryan Codd, Christopher P. Nelson, Christopher J. Walker, Claire Churchhouse, Albert de la Chapelle, Daryl E. Klein, Björn Nilsson, Peter W. F. Wilson, Kelly Cho, Saiju Pyarajan, J. Michael Gaziano, Nilesh J. Samani, Aviv Regev, Aarno Palotie, Benjamin M. Neale, John E. Dick, Pradeep Natarajan, Christopher J. O’Donnell, Mark J. Daly, Michael Milyavsky, Sekar Kathiresan, Vijay G. Sankaran; FinnGen; 23andMe Research Team
- Polygenic and clinical risk scores and their impact on age at onset and prediction of cardiometabolic diseases and common cancers (2020) Mars Nina, Koskela Jukka T., Ripatti Pietari, Kiiskinen Tuomo T. J., Havulinna Aki S., Lindbohm Joni V., Ahola-Olli Ari, Kurki Mitja, Karjalainen Juha, Palta Priit, Neale Benjamin M., Daly Mark, Salomaa Veikko, Palotie Aarno, Widén Elisabeth, Ripatti Samuli; FinnGen
- Polygenic Hyperlipidemias and Coronary Artery Disease Risk (2020)
- Circulation: Genomic and Precision Medicine
Ripatti P, Ramo JT, Mars NJ, Fu Y, Lin JK, Soderlund S, Benner C, Surakka I, Kiiskinen T, Havulinna AS, Palta P, Freimer NB, Widen E, Salomaa V, Tukiainen T, Pirinen M, Palotie A, Taskinen MR, Ripatti S; and on behalf of FinnGen
- Rare protein-altering variants in ANGPTL7 lower intraocular pressure and protect against glaucoma (2020) Tanigawa Yosuke, Wainberg Michael, Karjalainen Juha, Kiiskinen Tuomo, Venkataraman Guhan, Lemmelä Susanna, Turunen Joni A, Graham Robert R, Havulinna Aki S, Perola Markus, Palotie Aarno, Daly Mark J, Rivas Manuel A; FinnGen
- Suomen Lääketieteen Säätiö on kulkenut lääketieteen tutkimuksen rinnalla jo 60 vuotta (2020) Heikinheimo O, Elenius K, Remes A
- The guanine nucleotide exchange factor VAV3 participates in ERBB4-mediated cancer cell migration (2020)
- Journal of Biological Chemistry
Ojala VK, Knittle AM, Kirjalainen P, Merilahti JAM, Kortesoja M, Tvorogov D, Vaparanta K, Lin SJ, Kast J, Pulliainen AT, Kurppa KJ, Elenius K
- The role of polygenic risk and susceptibility genes in breast cancer over the course of life (2020) Mars N, Widen E, Kerminen S, Meretoja T, Pirinen M, Parolo PD, Palta P; FinnGen, Havulinna A, Palotie A, Kaprio J, Joensuu H, Daly M, Ripatti S
- Trans-biobank analysis with 676,000 individuals elucidates the association of polygenic risk scores of complex traits with human lifespan (2020) Sakaue S, Kanai M, Karjalainen J, Akiyama M, Kurki M, Matoba N, Takahashi A, Hirata M, Kubo M, Matsuda K, Murakami Y, Daly MJ, Kamatani Y, Okada Y
- An unbiased in vitro screen for activating epidermal growth factor receptor mutations (2019)
- Journal of Biological Chemistry
Chakroborty D, Kurppa KJ, Paatero I, Ojala VK, Koivu M, Tamirat MZ, Koivunen JP, Jänne PA, Johnson MS, Elo LL, Elenius K
- Decorin Expression in Human Vulva Carcinoma: Oncosuppressive Effect of Decorin cDNA Transduction on Carcinoma Cells (2019)
- Journal of Histochemistry and Cytochemistry
Marie C. Nyman, Anne B. Jokilammi, Pia C. Boström, Samu H. Kurki, Annele O. Sainio, Seija E. Grenman, Katri J. Orte, Sakari H. Hietanen, Klaus Elenius, Hannu T. Järveläinen
- Endothelial Cells Regulate Physiological Cardiomyocyte Growth via VEGFR2-Mediated Paracrine Signaling (2019) Kivelä R., Hemanthakumar K.A., Vaparanta K., Robciuc M., Izumiya Y., Kidoya H., Takakura N., Peng X., Sawyer D.B., Elenius K., Walsh K., Alitalo K.
- ErbB4 tyrosine kinase inhibition impairs neuromuscular development in zebrafish embryos (2019)
- Molecular Biology of the Cell
Paatero I, Veikkolainen V, Mäenpää M, Schmelzer E, Belting HG, Pelliniemi LJ, Elenius K
- Gamma-secretase-dependent signaling of receptor tyrosine kinases (2019) Merilahti JAM, Elenius K
- Genetic architecture of human plasma lipidome and its link to cardiovascular disease (2019) Tabassum R, Ramo JT, Ripatti P, Koskela JT, Kurki M, Karjalainen J, Palta P, Hassan S, Nunez-Fontarnau J, Kiiskinen TTJ, Soderlund S, Matikainen N, Gerl MJ, Surma MA, Klose C, Stitziel NO, Laivuori H, Havulinna AS, Service SK, Salomaa V, Pirinen M, Jauhiainen M, Daly MJ, Freimer NB, Palotie A, Taskinen MR, Simons K, Ripatti S, Jalanko A, Kaprio J, Donner K, Kaunisto M, Mars N, Dada A, Shcherban A, Ganna A, Lehisto A, Kilpelainen E, Brein G, Awaisa G, Harju J, Parr K, Parolo PD, Kajanne R, Lemmela S, Sipila TP, Sipila T, Lyhs U, Llorens V, Niiranen T, Kristiansson K, Mannikko L, Jimenez MG, Perola M, Wong R, Kilpi T, Hiekkalinna T, Jarvensivu E, Kaiharju E, Mattsson H, Laukkanen M, Laiho P, Lahteenmaki S, Sistonen T, Soini S, Ziemann A, Lehtonen A, Lertratanakul A, Georgantas B, Riley-Gillis B, Quarless D, Rahimov F, Heap G, Jacob H, Waring J, Davis JW, Smaoui N, Popovic R, Esmaeeli S, Waring J, Matakidou A, Challis B, Close D, Petrovski S, Karlsson A, Schleutker J, Pulkki K, Virolainen P, Kallio L, Mannermaa A, Heikkinen S, Kosma VM, Chen CY, Runz H, Liu J, Bronson P, John S, Landenpera S, Eaton S, Zhou W, Hendolin M, Tuovila O, Pakkanen R, Maranville J, Usiskin K, Hochfeld M, Plenge R, Yang R, Biswas S, Greenberg S, Laakkonen E, Kononen J, Paloneva J, Kujala U, Kuopio T, Laukkanen J, Kangasniemi E, Savinainen K, Laaksonen R, Arvas M, Ritari J, Partanen J, Hyvarinen K, Wahlfors T, Peterson A, Oh D, Chang D, Teng E, Strauss E, Kerchner G, Chen H, Chen H, Schutzman J, Michon J, Hunkapiller J, McCarthy M, Bowers N, Lu T, Bhangale T, Pulford D, Waterworth D, Kulkarni D, Xu FL, Betts J, Gordillo JE, Hoffman J, Auro K, McCarthy L, Ghosh S, Ehm M, Pitkanen K, Makela T, Loukola A, Joensuu H, Sinisalo J, Eklund K, Aaltonen L, Farkkila M, Carpen O, Kauppi P, Tienari P, Ollila T, Tuomi T, Meretoja T, Pitkaranta A, Turunen J, Hannula-Jouppi K, Pikkarainen S, Seitsonen S, Koskinen M, Palomaki A, Rinne J, Metsarinne K, Elenius K, Pirila L, Koulu L, Voutilainen M, Juonala M, Peltonen S, Aaltonen V, Loboda A, Podgornaia A, Chhibber A, Chu A, Fox C, Diogo D, Holzinger E, Eicher J, Gormley P, Mehta V, Wang XL, Kettunen J, Pylkas K, Kalaoja M, Karjalainen M, Hinttala R, Kaarteenaho R, Vainio S, Mantere T, Remes A, Huhtakangas J, Junttila J, Tasanen K, Huilaja L, Luodonpaa M, Hautala N, Karihtala P, Kauppila S, Harju T, Blomster T, Soininen H, Harvima I, Pihlajamaki J, Kaarniranta K, Pelkonen M, Laakso M, Hiltunen M, Kiviniemi M, Kaipiainen-Seppanen O, Auvinen P, Kalviainen R, Julkunen V, Malarstig A, Hedman A, Marshal C, Whelan C, Lehtonen H, Parkkinen J, Linden K, Kalpala K, Miller M, Bing N, McDonough S, Chen X, Hu XL, Wu Y, Auranen A, Jussila A, Uusitalo-Jarvinen H, Kankaanranta H, Uusitalo H, Peltola J, Kahonen M, Isomaki P, Laitinen T, Salmi T, Muslin A, Wang C, Chatelain C, Xu E, Auge F, Call K, Klinger K, Crohns M, Gossel M, Palin K, Rivas M, Siirtola H, Tabuenca JG
- Structural characterization of EGFR exon 19 deletion mutation using molecular dynamics simulation (2019) Tamirat M., Koivu M., Elenius K., Johnson M.
