Klaus Elenius
MD, PhD, professor
Research
ACTIONABLE RECEPTOR TYROSINE KINASE SIGNALING
Our goal is to understand how receptor tyrosine kinases (RTK) regulate the pathogenesis of human diseases, such as cancer. This information is needed for the development of molecularly targeted therapies. To recognize aberrations of RTK signaling in diseased tissue our laboratory also works on the molecular mechanism by which RTKs control normal processes, such as embryonic development. The work mainly focuses on the ErbB family of RTKs. Our laboratory has contributed to the field by e.g. by characterizing novel RTK signaling mechanisms, by identifying novel ErbB4 isoforms, and by determining the role of ErbBs and their ligands in angiogenesis.
Current topics
- Screens for predictive RTK mutations
- Novel RTK signaling mechanisms
- Development of preclinical models for development novel RTK inhibitors
- Sequencing of RTK inhibitor drug administration with cytotoxic agents
- In vitro “basket trials” with ErbB inhibitor drugs
- RTK signaling in angiogenesis and cardiovascular diseases
- RTKs in pediatric malignancies
- Biological role of novel ErbB4 isoforms in diseases and development
Elenius Lab members
- Anne Jokilammi, PhD
- Elli Narvi, PhD
- Deepankar Chakroborty, MSc
- Juho Heliste, MD
- Marika Koivu, MSc
- Johannes Merilahti, MSc
- Veera Ojala, MSc
- Janne Nordberg, MD
- Fred Saarinen, MSc
- Katri Vaparanta, MSc
- Kaisa Aalto, BM
- Maria Helkkula, BM
- Matias Mäenpää, BM
- Peppi Kirjalainen, BM
- Jori Torkkila, BM
Publications
- STAT5b is a key effector of NRG-1/ERBB4-mediated myocardial growth (2023) Vaparanta Katri, Jokilammi Anne, Paatero Ilkka, Merilahti Johannes A, Heliste Juho, Hemanthakumar Karthik Amudhala, Kivelä Riikka, Alitalo Kari, Taimen Pekka, Elenius Klaus
(Refereed journal article or data article (A1))
- An extracellular receptor tyrosine kinase motif orchestrating intracellular STAT activation (2022) Vaparanta Katri, Jokilammi Anne, Tamirat Mahlet, Merilahti Johannes AM, Salokas Kari, Varjosalo Markku, Ivaska Johanna, Johnson Mark S, Elenius Klaus
(Refereed journal article or data article (A1))
- An Unbiased Functional Genetics Screen Identifies Rare Activating ERBB4 Mutations (2022)
- Cancer Research Communications
Chakroborty Deepankar, Ojala Veera K., Knittle Anna M., Drexler Jasmin, Tamirat Mahlet, Ruzicka Regina, Bosch Karin, Woertl Johanna, Schmittner Susanne, Elo Laura L., Johnson Mark S., Kurppa Kari J., Solca Flavio, Elenius Klaus
(Refereed journal article or data article (A1))
- ANGPTL8 protein-truncating variant associated with lower serum triglycerides and risk of coronary disease (2021) Helkkula Pyry, Kiiskinen Tuomo, Havulinna Aki S, Karjalainen Juha, Koskinen Seppo, Salomaa Veikko, Daly Mark J, Palotie Aarno, Surakka Ida, Ripatti Samuli; FinnGen
(Refereed journal article or data article (A1))
- Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices (2021) Natarajan Pradeep, Pampana Akhil, Graham Sarah E., Ruotsalainen Sanni E., Perry James A., de Vries Paul S., Broome Jai G., Pirruccello James P., Honigberg Michael C., Aragam Krishna, Wolford Brooke, Brody Jennifer A., Antonacci-Fulton Lucinda, Arden Moscati, Aslibekyan Stella, Assimes Themistocles L., Ballantyne Christie M., Bielak Lawrence F., Bis Joshua C., Cade Brian E., Do Ron, Doddapaneni Harsha, Emery Leslie S., Hung Yi-Jen, Irvin Marguerite R., Khan Alyna T., Lange Leslie, Lee Jiwon, Lemaitre Rozenn N., Martin Lisa W., Metcalf Ginger, Montasser May E., Moon Jee-Young, Muzny Donna, O’Connell Jeffrey R., Palmer Nicholette D., Peralta Juan M., Peyser Patricia A., Stilp Adrienne M., Tsai Michael, Wang Fei Fei, Weeks Daniel E., Yanek Lisa R., Wilson James G., Abecasis Goncalo, Arnett Donna K., Becker Lewis C., Blangero John, Boerwinkle Eric, Bowden Donald W., Chang Yi-Cheng, Chen Yii-Der I., Choi Won Jung, Correa Adolfo, Curran Joanne E., Daly Mark J., Dutcher Susan K., Ellinor Patrick T., Fornage Myriam, Freedman Barry I., Gabriel Stacey, Germer Soren, Gibbs Richard A., He Jiang, Hveem Kristian, Jarvik Gail P., Kaplan Robert C., Kardia Sharon L. R., Kenny Eimear, Kim Ryan W., Kooperberg Charles, Laurie Cathy C., Lee Seonwook, Lloyd-Jones Don M., Loos Ruth J. F., Lubitz Steven A., Mathias Rasika A., Martinez Karine A. Viaud, McGarvey Stephen T., Mitchell Braxton D., Nickerson Deborah A., North Kari E., Palotie Aarno, Park Cheol Joo, Psaty Bruce M., Rao D. C., Redline Susan, Reiner Alexander P., Seo Daekwan, Seo Jeong-Sun, Smith Albert V., Tracy Russell P., Vasan Ramachandran S., Kathiresan Sekar, Cupples L. Adrienne, Rotter Jerome I., Morrison Alanna C., Rich Stephen S., Ripatti Samuli, Willer Cristen; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; FinnGen, Peloso Gina M.
(Refereed journal article or data article (A1))
- Combined genetic and chemical screens indicate protective potential for EGFR inhibition to cardiomyocytes under hypoxia (2021) Heliste Juho, Jokilammi Anne, Vaparanta Katri, Paatero Ilkka, Elenius Klaus
(Refereed journal article or data article (A1))
- Geenidiagnostiikkaan perustuva syövän hoito - ovatko odotukset toteutuneet? (2021) Alanne Erika, Joensuu Heikki, Elenius Klaus
(Refereed review article in scientific journal (A2))
- Geeniohjatun syövän hoidon työryhmä hoitopäätösten apuna : Läntisen syöpäkeskuksen kokemus (2021) Alanne Erika, Orte Katri, Haanpää Maria, Kankuri-Tammilehto Minna, Silvoniemi Maria, Sundvall Maria, Hietanen Sakari, Boström Pia, Laine Jukka, Jaakkola Panu, Minn Heikki, Kallajoki Markku, Kairisto Veli, Elenius Klaus, Vihinen Pia
(Article in trade journal or blog post (D1))
- Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries (2021) Gharahkhani Puya, Jorgenson Eric, Hysi Pirro, Khawaja Anthony P., Pendergrass Sarah, Han Xikun, Ong Jue Sheng, Hewitt Alex W., Segrè Ayellet V., Rouhana John M., Hamel Andrew R., Igo Jr Robert P., Choquet Helene, Qassim Ayub, Josyula Navya S., Bailey Jessica N. Cooke, Bonnemaijer Pieter W. M., Iglesias Adriana, Siggs Owen M., Young Terri L., Vitart Veronique, Thiadens Alberta A. H. J., Karjalainen Juha, Uebe Steffen, Melles Ronald B., Nair K. Saidas, Luben Robert, Simcoe Mark, Amersinghe Nishani, Cree Angela J., Hohn Rene, Poplawski Alicia, Chen Li Jia, Rong Shi-Song, Aung Tin, Eranga Nishanthie Vithana, NEIGHBORHOOD consortium, ANZRAG consortium, Biobank Japan project, UK Biobank Eye and Vision Consortium, GIGA study group, 23 and Me Research Team, Tamiya Gen, Shiga Yukihiro, Yamamoto Masayuki, Nakazawa Toru, Currant Hannah, Birney Ewan, Wang Xin, Auton Adam, Lupton Michelle K., Martin Nicholas G., Ashaye Adeyinka, Olawoye Olusola, Williams Susan E., Akafo Stephen, Ramsay Michele, Hashimoto Kazuki, Kamatani Yoichiro, Akiyama Masato, Momozawa Yukihide, Foster Paul J., Khaw Peng T., Morgan James E., Strouthidis Nicholas G., Kraft Peter, Kang Jae H., Pang Chi Pui, Pasutto Francesca, Mitchell Paul, Lotery Andrew J., Palotie Aarno, van Duijn Cornelia, Haines Jonathan L., Hammond Chris, Pasquale Louis R., Klaver Caroline C. W., Hauser Michael, Khor Chiea Chuen, Mackey David A., Kubo Michiaki, Cheng Ching-Yu, Craig Jamie E., MacGregor Stuart, Wiggs Janey L.; FinnGen Study
(Refereed journal article or data article (A1))
- Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection (2021) Zekavat Seyedeh M., Lin Shu-Hong, Bick Alexander G., Liu Aoxing, Paruchuri Kaavya, Wang Chen, Uddin Md Mesbah, Ye Yixuan, Yu Zhaolong, Liu Xiaoxi, Kamatani Yoichiro, Bhattacharya Romit, Pirruccello James P., Pampana Akhil, Loh Po-Ru, Kohli Puja, McCarroll Steven A., Kiryluk Krzysztof, Neale Benjamin, Ionita-Laza Iuliana, Engels Eric A., Brown Derek W., Smoller Jordan W., Green Robert, Karlson Elizabeth W., Lebo Matthew, Ellinor Patrick T., Weiss Scott T., Daly Mark J., The Biobank Japan Project, Terao Chikashi, Zhao Hongyu, Ebert Benjamin L., Reilly Muredach P., Ganna Andrea, Machiela Mitchell J., Genovese Giulio, Natarajan Pradeep; FinnGen Consortium
(Refereed journal article or data article (A1))
- Identification of Predictive ERBB Mutations by Leveraging Publicly Available Cell Line Databases (2021)
- Molecular Cancer Therapeutics
Koivu Marika KA, Chakroborty Deepankar, Tamirat Mahlet Z, Johnson Mark S, Kurppa Kari J, Elenius Klaus
(Refereed journal article or data article (A1))
- Structural Basis for the Functional Changes by EGFR Exon 20 Insertion Mutations (2021) Tamirat Mahlet Z., Kurppa Kari J., Elenius Klaus, Johnson Mark S.
(Refereed journal article or data article (A1))
- The impact of non-additive genetic associations on age-related complex diseases (2021) Guindo-Martinez Marta, Amela Ramon, Bonàs-Guarch Silvia, Puiggros Montserrat, Salvoro Cecilia, Miguel-Escalada Irene, Carey Caitlin E, Cole Joanne B, Rüeger Sina, Atkinson Elizabeth, Leong Aaron, Sanchez Friman, Ramon-Cortes Cristian, Ejarque Jorge, Palmer Duncan S, Kurki Mitja, Aragam Krishna, Florez Jose C, Badia Rosa M, Mercader Josep M, Torrents David; FinnGen
(Refereed journal article or data article (A1))
- Therapeutic Potential of Targeting the SUMO Pathway in Cancer (2021) Kukkula Antti, Ojala Veera K., Mendez Lourdes M, Sistonen Lea, Elenius Klaus, Sundvall Maria
(Refereed review article in scientific journal (A2))
- A Platelet Function Modulator of Thrombin Activation Is Causally Linked to Cardiovascular Disease and Affects PAR4 Receptor Signaling (2020)
- American Journal of Human Genetics
Rodriguez Benjamin AT, Bhan Arunoday, Beswick Andrew, Elwood Peter C, Niiranen Teemu J, Salomaa Veikko, Tregouet David-Alexandre, Morange Pierre-Emmanuel, Civelek Mete, Ben-Shlomo Yoav, Schlaeger Thorsten, Chen Ming-Huei, Johnson Andrew D; FinnGen Study
(Refereed journal article or data article (A1))
- Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation (2020)
- Journal of Visualized Experiments
Mahlet Z. Tamirat, Kari J. Kurppa, Klaus Elenius, Mark S. Johnson
(Refereed journal article or data article (A1))
- Erbb4 regulates the oocyte microenvironment during folliculogenesis (2020) Veikkolainen V, Ali N, Doroszko M, Kiviniemi A, Miinalainen I, Ohlsson C, Poutanen M, Rahman N, Elenius K, Vainio SJ, Naillat F
(Refereed journal article or data article (A1))
- Genetic analysis of obstructive sleep apnoea discovers a strong association with cardiometabolic health (2020)
- European Respiratory Journal
Strausz S, Ruotsalainen S, Ollila HM, Karjalainen J, Kiiskinen T, Reeve M, Kurki M, Mars N, Havulinna AS, Luonsi E, Mansour Aly D, Ahlqvist E, Teder-Laving M, Palta P, Groop L, Mäkitie A, Mägi R, Bachour A, Salomaa V, Palotie A, Tuomi T, Ripatti S, Palotie T, Ripatti S; FinnGen research group
(Refereed journal article or data article (A1))
- Genetic and functional implications of an exonic TRIM55 variant in heart failure (2020)
- Journal of Molecular and Cellular Cardiology
Juho Heliste, Himanshu Chheda, Ilkka Paatero, Tiina A. Salminen, Yevhen Akimoc, Jere Paavola, Klaus Elenius, Tero Aittokallio
(Refereed journal article or data article (A1))
- Genomic prediction of alcohol-related morbidity and mortality (2020) Kiiskinen T, Mars NJ, Palviainen T, Koskela J, Ramo JT, Ripatti P, Ruotsalainen S, Palotie A, Madden PAF, Rose RJ, Kaprio J, Salomaa V, Makela P, Havulinna AS, Ripatti S
(Refereed journal article or data article (A1))