Tero Aittokallio
PhD
teanai@utu.fi Tykistökatu 6 A Turku ORCID identifier: https://orcid.org/orcid.org/0000-0002-0886-9769 |
Tero Aittokallio received his PhD in Applied Mathematics from the University of Turku in 2001, under the supervision of Prof. Mats Gyllenberg. He then did his post-doctoral training in the Systems Biology Lab at the Institut Pasteur (2006-2007), with Dr. Benno Schwikowski, where he focused on network biology applications using high-throughput experimental assays and network analysis tools such as Cytoscape. In 2007, Dr. Aittokallio launched his independent career as a principal investigator in the Turku Biomathematics Research Group, where he received a five-year appointment as an Academy of Finland Research Fellow (2007-2012). Tero Aittokallio joined Institute for Molecular Medicine Finland (FIMM) as EMBL Group Leader in the fall of 2011, and was selected as Professor of Statistics and Applied Mathematics at University of Turku in 2015.
Aittokallio's research group focuses on developing and applying integrated computational-experimental approaches to tackle biomedical questions, such as how genes function as interaction networks to carry out and regulate cellular processes, how alterations in these networks contribute to complex traits, such as human diseases, and where and how in the disease network one should target to optimally inhibit the disease phenotypes, such as tumor growth.
Computational statistics.
Scientific computing.
- Liver lipid metabolism is altered by increased circulating estrogen to androgen ratio in male mouse (2016)
- Journal of Proteomics
(A1 Refereed original research article in a scientific journal) - Multi-Omics Studies towards Novel Modulators of Influenza A Virus-Host Interaction (2016)
- Viruses
(A2 Refereed review article in a scientific journal ) - Novel therapeutic possibilities for chemorefractory ovarian cancer patients identified by functional ex vivo drug sensitivity testing of primary cells (2016)
- International Journal of Gynecological Cancer
(Other publication) - Optimized design and analysis of preclinical intervention studies in vivo (2016)
- Scientific Reports
(A1 Refereed original research article in a scientific journal) - Phosphoproteomics to Characterize Host Response During Influenza A Virus Infection of Human Macrophages (2016)
- Molecular and Cellular Proteomics
(A1 Refereed original research article in a scientific journal) - Pro-apoptotic functions of AMPK revealed by Myc (2016)
- Molecular Cancer Research
(Other publication) - Systematic drug screening reveals specific vulnerabilities and co-resistance patterns in endocrine-resistant breast cancer (2016)
- BMC Cancer
(A1 Refereed original research article in a scientific journal) - The Hydroxysteroid (17 beta) Dehydrogenase Family Gene HSD17B12 Is Involved in the Prostaglandin Synthesis Pathway, the Ovarian Function, and Regulation of Fertility (2016)
- Endocrinology
(A1 Refereed original research article in a scientific journal) - Transcriptional response networks for elucidating mechanisms of action of multitargeted agents (2016)
- Drug Discovery Today
(A2 Refereed review article in a scientific journal ) - UNSTABLE LDL - NOVEL MECHANISM OF ATHEROGENESIS AND LINK TO CARDIOVASCULAR DEATHS (2016)
- Atherosclerosis
(Other publication) - Dasatinib and everolimus show synergistic growth inhibition with paclitaxel in an ovarian granulosa cell tumor model (2015)
- Cancer Research
(Other publication) - From drug response profiling to target addiction scoring in cancer cell models (2015)
- Disease Models and Mechanisms
(A1 Refereed original research article in a scientific journal) - High-throughput drug sensitivity and resistance testing of ovarian cancer cell lines provides useful strategy for assessing drug repositioning and therapeutic possibilities of emerging drugs (2015)
- Clinical Cancer Research
(Other publication) - Identification of drug candidates and repurposing opportunities through compound-target interaction networks (2015)
- Expert Opinion on Drug Discovery
(A2 Refereed review article in a scientific journal ) - Identification of subgroups of triple negative breast cancer cells with selective responses to mTOR, CDK, mitotic and proteasome inhibitors (2015)
- Cancer Research
(Other publication) - Impact of normalization methods on high-throughput screening data with high hit rates and drug testing with dose-response data (2015)
- Bioinformatics
(A1 Refereed original research article in a scientific journal) - JAK1/2 and BCL2 Inhibitors Synergize to Counter-Act Bone Marrow Stromal Cell-Induced Protection of AML (2015)
- Blood
(Other publication) - Label-free quantitative phosphoproteomics with novel pairwise abundance normalization reveals synergistic RAS and CIP2A signaling (2015)
- Scientific Reports
(A1 Refereed original research article in a scientific journal) - MicroRNA-135b regulates ERα, AR and HIF1AN and affects breast and prostate cancer cell growth (2015)
- Molecular Oncology
(A1 Refereed original research article in a scientific journal) - Novel therapeutic possibilities for chemorefractory ovarian cancer patients identified by functional ex vivo drug sensitivity testing of primary cells from ascites (2015)
- Cancer Research
(Other publication)